ID S3DB84_GLAL2 Unreviewed; 515 AA.
AC S3DB84;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=phenylalanine--tRNA ligase {ECO:0000256|ARBA:ARBA00012814};
DE EC=6.1.1.20 {ECO:0000256|ARBA:ARBA00012814};
DE AltName: Full=Phenylalanyl-tRNA synthetase alpha subunit {ECO:0000256|ARBA:ARBA00030612};
GN ORFNames=GLAREA_00381 {ECO:0000313|EMBL:EPE29221.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE29221.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE29221.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Phe-tRNA synthetase alpha subunit type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00006703}.
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DR EMBL; KE145367; EPE29221.1; -; Genomic_DNA.
DR RefSeq; XP_008083330.1; XM_008085139.1.
DR AlphaFoldDB; S3DB84; -.
DR STRING; 1116229.S3DB84; -.
DR GeneID; 19459439; -.
DR KEGG; glz:GLAREA_00381; -.
DR eggNOG; KOG2784; Eukaryota.
DR HOGENOM; CLU_025086_2_0_1; -.
DR OMA; QIEGWVM; -.
DR OrthoDB; 4619at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00496; PheRS_alpha_core; 1.
DR Gene3D; 1.10.10.2320; -; 1.
DR Gene3D; 1.10.10.2330; -; 1.
DR Gene3D; 3.30.1370.240; -; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004529; Phe-tRNA-synth_IIc_asu.
DR InterPro; IPR002319; Phenylalanyl-tRNA_Synthase.
DR InterPro; IPR040725; PheRS_DBD3.
DR NCBIfam; TIGR00468; pheS; 1.
DR PANTHER; PTHR11538:SF40; PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR11538; PHENYLALANYL-TRNA SYNTHETASE; 1.
DR Pfam; PF18553; PheRS_DBD3; 1.
DR Pfam; PF01409; tRNA-synt_2d; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 231..508
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 515 AA; 58170 MW; 7BFE87D204AC2190 CRC64;
MATSQEVQQG DLPSEVLQAL SQNDPILSAT TFPSIRATEL KGALDRLASR SMITYETIDK
EEPVLEPEAL EIAANGSHEA RVFEALKQAM DGLTVSELEA AVGDKNVVKV GQGKAFKSKW
IAKGKEGRLI ASTDSIQDVT QQQLQVIQKT SSHPDPKVIT DLKKRKLVKM QKITSFKIHK
GPKFALEIVK EETDLTADML ASGAWKTAAF KPYNFKSLGA DQNAGALHPL NKVRHEFRQI
FFEMGFEEMP TNRYVETGFW NFDALFVPQQ HPARDLQDTF YISDPKTADK PHAESQDDKG
DYESYWENVQ EVHQDGKYGS IGYRYPWAED ESLRLVLRTH TTAISTAMLH KLASQKGPDG
RPPPARYFSI DRVFRNETVD ATHLAEFHQV EGVIADYGLS LGGLMEFMEI FFNKMGIEDL
RFKPAYNPYT EPSMEIFSFH KGLNKLVEIG NSGMFRPEML ESMGLPKDMR VFGWGLSLER
PTMIKYKVNN IRELLGHKVD LSFIERNPAV RLEKA
//
