ID S3DBQ0_GLAL2 Unreviewed; 421 AA.
AC S3DBQ0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=[acyl-carrier-protein] S-malonyltransferase {ECO:0000256|ARBA:ARBA00013258};
DE EC=2.3.1.39 {ECO:0000256|ARBA:ARBA00013258};
GN ORFNames=GLAREA_10233 {ECO:0000313|EMBL:EPE34539.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE34539.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE34539.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78449; EC=2.3.1.39;
CC Evidence={ECO:0000256|ARBA:ARBA00000936};
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DR EMBL; KE145356; EPE34539.1; -; Genomic_DNA.
DR RefSeq; XP_008078474.1; XM_008080283.1.
DR AlphaFoldDB; S3DBQ0; -.
DR STRING; 1116229.S3DBQ0; -.
DR GeneID; 19469280; -.
DR KEGG; glz:GLAREA_10233; -.
DR eggNOG; KOG2926; Eukaryota.
DR HOGENOM; CLU_030558_5_0_1; -.
DR OMA; AANYNCP; -.
DR OrthoDB; 2265421at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR PANTHER; PTHR42681; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42681:SF1; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 57..403
FT /note="Malonyl-CoA:ACP transacylase (MAT)"
FT /evidence="ECO:0000259|SMART:SM00827"
SQ SEQUENCE 421 AA; 46636 MW; 61C85FAB87E97C11 CRC64;
MRSLATGLPK RCRYAPRRQL PREVSHGTCL TRQQPISNHI QVRHASTKPH RPRTAIFFPG
QGVQRVGMLT PWLEAFPATA KPAVEEIDHL LGYKLSTIIE EGPNSLLTAT GNAQPAIMAS
SLLILRILER EFGFQTAERV DVTLGHSLGE FAALVAGGFV QFEDSLYLVR KRAELMAESS
QKAREEFGGD YGMIALVTEP NHLASLIDSI HEFLGYHSAG SKSESALDVP PIQQVLIANI
NSKNQIVLSG NIAAIKQLLT HIRQFGGHDP RAVRLKSDSP FHSPLMKPAA TAMRKLLDGK
SRVKGKEDQD IVTFPGKMEC ISNVSARPFT GAEDLKDLWA RQCVETVRWW DSIKYLDQEQ
KVRRWIGIGP GKVGRNLVGK EVGMRGRDVV KGGGVWGISD PKEIEEMLKA LDDTENIRDD
E
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