ID S3DHI0_GLAL2 Unreviewed; 917 AA.
AC S3DHI0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=DNA repair protein MutS, III {ECO:0000313|EMBL:EPE26043.1};
GN ORFNames=GLAREA_01955 {ECO:0000313|EMBL:EPE26043.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE26043.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE26043.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KE145371; EPE26043.1; -; Genomic_DNA.
DR RefSeq; XP_008087362.1; XM_008089171.1.
DR AlphaFoldDB; S3DHI0; -.
DR STRING; 1116229.S3DHI0; -.
DR GeneID; 19461013; -.
DR KEGG; glz:GLAREA_01955; -.
DR eggNOG; KOG0219; Eukaryota.
DR HOGENOM; CLU_002472_10_0_1; -.
DR OMA; LVRFPQK; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 731..747
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 917 AA; 102998 MW; 774D8B42300E5425 CRC64;
MSSRPELKVD DESSFIKFFK NLPAKDDDTI RIFDRGDWYT AHGDDASFIA RTVYKTTSVL
RQLGKNDSTG LPSVTLSITV FRNFLREALF RLGKRIEVWA SNGGRMNWKV SKQASPGNLQ
DIEEELGGQF DAAPIILAVK VSAKASEARN VGVCFADASV RELGVSEFLD NDLYSNFESL
LIQLGVKECL IQVDKGDKNV EMAKLRAIID SCGIAISERP GGDFGTKDID QDLARLLKDE
KSAGILPQTD LKLAMGSAAA LIKYLGVMHD NSNFGQYQLY QHDLSQFMKL DASALKALNL
MPGPRDGSKT MSLYGLLNHC KTPIGSRLMA QWLKQPLMSK DEIEKRQQLV EAFVEDTELR
QTMQEEHLRS IPDLYRLAKR FQRKMANLED VIRAYQVVLR LPNIIATLEG VIDEQYRNPL
DEAYTIKLRD YSDSLAKLLE MVETTVDLEA MENHEYKIKP EFDDGLRIIQ RKLEKSRHEM
DVEHRAASKD LGQEIDKKLF LENHKVHGWC MRLTRAEAGC IRNNKKYQEC STQKNGVFFT
THKLQSCRRE FDQLAENYNR TQSSLVNEVV SVAASYCPVI EFLAGVIAHL DVIVSFAHCS
VHAPTSYVRP KMHPRGEGST ILKEARHPCM EMQDDIQFIT NDVTLERGSS QFLIITGPNC
GGKSTYIRQI GVIALMAQIG CFVPCSEAEL TIFDCILARV GASDSQLKGV STFMAEMLET
ANILKSATSE SLIIIDELGR GTSTYDGFGL AWAISEHIIK EIGCFSMFAT HFHELTALVD
TYPQVQNLHV VAHIDDNGKA KREVTLLYKV EDGICDQSFG IHVAELVRFP EKVVNMAKRK
ADELEDFTSK HEGATVKYEK EDVETGSALL KDVLLRWKAG CEGKQMSKDE KIGLMRELVK
GDDKLLANPF FQSIKAL
//
