ID S3DMN6_GLAL2 Unreviewed; 461 AA.
AC S3DMN6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Multidrug resistance efflux transporter EmrE {ECO:0000313|EMBL:EPE27758.1};
GN ORFNames=GLAREA_04549 {ECO:0000313|EMBL:EPE27758.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE27758.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE27758.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A
CC subfamily. {ECO:0000256|ARBA:ARBA00009976}.
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DR EMBL; KE145369; EPE27758.1; -; Genomic_DNA.
DR RefSeq; XP_008085117.1; XM_008086926.1.
DR AlphaFoldDB; S3DMN6; -.
DR STRING; 1116229.S3DMN6; -.
DR GeneID; 19463604; -.
DR KEGG; glz:GLAREA_04549; -.
DR eggNOG; KOG2234; Eukaryota.
DR HOGENOM; CLU_024645_2_0_1; -.
DR OMA; VFVWYLV; -.
DR OrthoDB; 200085at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015165; F:pyrimidine nucleotide-sugar transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR007271; Nuc_sug_transpt.
DR NCBIfam; TIGR00803; nst; 1.
DR PANTHER; PTHR10231; NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER; 1.
DR PANTHER; PTHR10231:SF36; UDP-N-ACETYLGLUCOSAMINE TRANSPORTER; 1.
DR Pfam; PF04142; Nuc_sug_transp; 1.
DR PIRSF; PIRSF005799; UDP-gal_transpt; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 407..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..421
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 50580 MW; AF35A5344F946348 CRC64;
MGDPQKTPSV MGVNMKLVSL VTLTFQNSAL ILIMHYSRIM PISGQHRYFT STAVLLNEVI
KLAVSLTIAM YDISRTLPPS TPATVLFEQL YGSVFSGDSW KLAIPATLYT LQNSLQYVAV
SNLDAILTTA VFSVTMLGRS LSNKRWVALV ILTLGVAVVQ LPSGAQDTSV YDSINDAQSR
FYFPRSFHEI GQLGNGAAEV ARELTKRGIE TLSGGLTKRS ATYEGIQEDM GLVKPLMNYS
IGLSAVLSAA AISGLAGVYF EKVLKESNTY VTVWTRNVQL SFYSLFPALI FGVLMKDGEE
IAKEGFFVGY NGVVWTAIVF QSLGGVLVAM CINYADNIAK NFATSISIIL SFLFSVWFFD
FKVTLNFLVG TALVIFSTYL YSGQEGKRNR PPPINIVDYE KTTIDNGYTP RFEEDKQLGA
TPDIRPLESL KSAGLSTSRP SSPMRHHSRV GSSRKGIKRD D
//
