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Database: UniProt
Entry: S3DNC0_GLAL2
LinkDB: S3DNC0_GLAL2
Original site: S3DNC0_GLAL2 
ID   S3DNC0_GLAL2            Unreviewed;      1108 AA.
AC   S3DNC0;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   05-JUN-2019, entry version 36.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=GLAREA_06604 {ECO:0000313|EMBL:EPE33591.1};
OS   Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Helotiaceae; Glarea.
OX   NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE33591.1, ECO:0000313|Proteomes:UP000016922};
RN   [1] {ECO:0000313|EMBL:EPE33591.1, ECO:0000313|Proteomes:UP000016922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX   PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA   Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA   Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT   "Genomics-driven discovery of the pneumocandin biosynthetic gene
RT   cluster in the fungus Glarea lozoyensis.";
RL   BMC Genomics 14:339-339(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KE145357; EPE33591.1; -; Genomic_DNA.
DR   RefSeq; XP_008078743.1; XM_008080552.1.
DR   STRING; 101852.XP_008078743.1; -.
DR   EnsemblFungi; EPE33591; EPE33591; GLAREA_06604.
DR   GeneID; 19465657; -.
DR   KEGG; glz:GLAREA_06604; -.
DR   KO; K02327; -.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000016922; Unassembled WGS sequence.
DR   GO; GO:0043625; C:delta DNA polymerase complex; IEA:EnsemblFungi.
DR   GO; GO:0000784; C:nuclear chromosome, telomeric region; IEA:EnsemblFungi.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:1904161; P:DNA synthesis involved in UV-damage excision repair; IEA:EnsemblFungi.
DR   GO; GO:1903459; P:mitotic DNA replication lagging strand elongation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016922};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      130    477       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      541    972       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1010   1084       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     62       Disordered. {ECO:0000256|MobiDB-lite:
FT                                S3DNC0}.
FT   COILED       69     89       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     14     34       Polar. {ECO:0000256|MobiDB-lite:S3DNC0}.
FT   COMPBIAS     42     62       Polar. {ECO:0000256|MobiDB-lite:S3DNC0}.
SQ   SEQUENCE   1108 AA;  125173 MW;  553635D57C487E23 CRC64;
     MAPSRVPQKR ILADATNARN NVPSTPTSSK KRKLEPIASS PAARFKNSQN GPKGKLASSQ
     PSHFETEVLE KMTQDMAGLK KHNSEKDQQW KRPELGEFDP QTEMLSFQQI EIEQGTLRGG
     RATAKLYGVT ENGHSVLLHV TGFLHYLYVE APVGFKVSDC EKFKTFLDSQ VAQSGPAIHS
     VNLVKRESLY YYKGNQQFAY IKITVTSPNY VATVRGTIER CQANYQRMWK PVLDNEGKGH
     IQTYDMVDYL TRFMIDCDIA GMSWVEAPPK SYTMTPKHER QSNCQIEAEI EYRDLITHKP
     VGEWAKMAPL RTLSFDIECA GRKGIFPEAE IDPVIQIANV VTRYGEKKPF VRNVFCLDAT
     SVIVNTQVLT FKREEELLAR WRDFLEDVDP DIIIGYNICN FDFPYLLKRA NHLKVQDFSL
     WTRHKNKRSE ATAARFSSKQ MGNRESQATN IEGRLQLDLL QLIQRDHQLR SYTLNSVCAQ
     FLGEQKEDVH HTMITELFNG TPETRRRLAV YCLKDAYLPQ RLMDKLSCLE NLTEMARVTG
     VPFNMLLSRG QQVKFVSQVF RKAREQKLVV PNLKTSGAEQ DYDGATVIDP TRGYYDVPIA
     TLDFASLYPS IIQAHNLCYT TLLTKEAVKT LDLKEGEDYI VTPTKEMFCT AARRKGLLSQ
     ILEELLGARK QAKRELAQET DPFKKAVLNG RQLALKVSAN SVYGLTGAAV GKMPCLQIAS
     STTAYGRKMI EKTKAEVEAE YTIANGYSHD AKVIYGDTDS VMVKFGVQDL AGAMELGEKA
     AQFVSKKFEK PIKLEFEKVY YPYLLINKKR YAGLYWTNPD KYDKMDTKGI ETVRRDNCRL
     VQNVIETVLR MILIDRDVPG AESYVKDTIS DLLQNKIDMS KLVITKALSK DDYVGKQAHV
     ELAARMKKRD AGSAPGLGDR VAYVIIKGSA GAKNFERSED PIYVLENNIP VDTKYYLDNQ
     LAKPLGRIFE PIFGETRANS LLTGDHTRSV AIAASTVGGL MKFTKKTFTC MGCKKPLTRK
     EEAGGAVCSD CAPRIGELYT KTLNKVSDLE VRFSRLWTQC QRCQGSVHCE VICSSKDCPI
     FYMRMKAKKD VEDAGKELVR FDKDSAAW
//
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