ID S3DPK5_GLAL2 Unreviewed; 566 AA.
AC S3DPK5;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
GN ORFNames=GLAREA_07034 {ECO:0000313|EMBL:EPE34021.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE34021.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE34021.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M.
CC {ECO:0000256|ARBA:ARBA00025513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361124}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
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DR EMBL; KE145357; EPE34021.1; -; Genomic_DNA.
DR RefSeq; XP_008079173.1; XM_008080982.1.
DR AlphaFoldDB; S3DPK5; -.
DR STRING; 1116229.S3DPK5; -.
DR GeneID; 19466087; -.
DR KEGG; glz:GLAREA_07034; -.
DR eggNOG; KOG2261; Eukaryota.
DR HOGENOM; CLU_010580_1_0_1; -.
DR OMA; HIKWNEG; -.
DR OrthoDB; 1343374at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361124}.
FT DOMAIN 9..152
FT /note="Enhancer of polycomb-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10513"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 65158 MW; 7D3F771DADB86E8D CRC64;
MAPAQRVVRQ RKLNKSTPQS VLREEQIESA EYDSLQNQYH VETGVERSEE NEYHLQVALK
ANSNGSEKDE VKEIPAPPAV EGADINYDEL YSLEFHQPDT YIRFSDTVEE ACGCPYDMTT
EDDVFLKAYN QKKTPSHRCS EDKFEKIMDV FELTAQSHAP FAAVDNTVVP FDKMKPELIK
QEMGDSTAPL RANVAEKLIT LAKDIYEHWR ERRQASGNNP LQPSLKFETH QENDDGDPYV
CFRRRDVRPT RKTRARDVQS TDKLKRLRRE IEEGRHLVAL ACHREELKRQ VINTDKLIFE
ARAKVKEAKV RLGIKGDDED LINQRPQKRK VSDYPQMQRV PGTQLRLPAR PDGRPLDADL
VMLSDVLAQK ENLLQREIEE KTLQHRKWNA NHIDLTREPL SPVNGHGPDT GFRPATAQYQ
YLMTPPSSVT SETFDQPSPA QEVTEPAKFR YNSPEEDENR SRPAYRRRIG RGGRLWIDRR
GMSSCVKTLD DEIRSDRYKY DQDDDDEQPV YEMDPYDTRA LKFRATIPFP AHLAQNSRRV
EPNRPAVQSP PNSRTAAAPQ PAVAPT
//
