ID S3DSB5_GLAL2 Unreviewed; 394 AA.
AC S3DSB5;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Translation initiation factor eIF2B subunit alpha {ECO:0000256|ARBA:ARBA00044208};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit alpha {ECO:0000256|ARBA:ARBA00044236};
GN ORFNames=GLAREA_10536 {ECO:0000313|EMBL:EPE34841.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE34841.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE34841.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; KE145355; EPE34841.1; -; Genomic_DNA.
DR RefSeq; XP_008077828.1; XM_008079637.1.
DR AlphaFoldDB; S3DSB5; -.
DR STRING; 1116229.S3DSB5; -.
DR GeneID; 19469582; -.
DR KEGG; glz:GLAREA_10536; -.
DR eggNOG; KOG1466; Eukaryota.
DR HOGENOM; CLU_016218_0_1_1; -.
DR OMA; GDWESCK; -.
DR OrthoDB; 51607at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.1070; Translation initiation factor eIF-2B, N-terminal domain; 1.
DR InterPro; IPR042528; elF-2B_alpha_N.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR45860; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA; 1.
DR PANTHER; PTHR45860:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transferase {ECO:0000313|EMBL:EPE34841.1}.
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 394 AA; 42201 MW; FEFD8FC5ECE7142D CRC64;
MDDTASTTRK TSTISSPNYS AASPSFYEGS TTPPPLTGHP PGLNRMATVG NVPQSGAGGK
SEAFDIVKTY HRLLAEDPEL TMPVAAIEAL IELLVQSRAV TVFETLDLVK TQSDYLKSRI
PNSISLSAGT DLFQRYMISS LNPRSTGNFD AVRQHLLSNG RLFVSRAKAG RERIANYGRH
FVRDGSVVLT HGGSRVVGAL LSKAADASAS GGNVRFNVIY VMNDARNSES KAVVSALRAK
GVPVATIPEG AVGYAMGKVD LVMVGAEGVV ENGGIISRLG TYQIGLLAKA ADKPFYVAAE
SHKFVRLYPL DQFDLGFDQE VIKFTTEDEG EADEYGVKTP RVVERPEYFG APDVPETPIE
AVDYTPPGLV TALITEGGVL TPSAVSEELI NVWW
//
