ID S3DZ21_GLAL2 Unreviewed; 327 AA.
AC S3DZ21;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Aminoacid dehydrogenase-like, N-terminal {ECO:0000313|EMBL:EPE31593.1};
GN ORFNames=GLAREA_12349 {ECO:0000313|EMBL:EPE31593.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE31593.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE31593.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
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DR EMBL; KE145361; EPE31593.1; -; Genomic_DNA.
DR RefSeq; XP_008081322.1; XM_008083131.1.
DR AlphaFoldDB; S3DZ21; -.
DR STRING; 1116229.S3DZ21; -.
DR GeneID; 19471390; -.
DR KEGG; glz:GLAREA_12349; -.
DR eggNOG; KOG0089; Eukaryota.
DR HOGENOM; CLU_031413_0_0_1; -.
DR OMA; CKVITAE; -.
DR OrthoDB; 2232005at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01079; NAD_bind_m-THF_DH; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR035812; m-THF_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000672; THF_DH/CycHdrlase.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR PRINTS; PR00085; THFDHDRGNASE.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 17..120
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 142..313
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
SQ SEQUENCE 327 AA; 35328 MW; 6D99F1FFA30AA6DE CRC64;
MAAPTPANHC KVVLAGSIAK ALLAEVAEGL SKLNEKPKLV GLLANGDPAG QMYADWSAKT
CRENGFDFDL KVITKEEIEE AILAANADPT INGIIVYYPI YSSGQDSYIK ELVDLTKDVE
GLTHKYVFNM YQNTRFLDPP TNNQKSILPC TPLACVKVLE YLQIYNSILP YGNRLFGKTI
TVINRSEVVG RPLAALLAND GAKVYSVDLD GIQIFTRGAG IKKKHHEVEE LPKTFSLADC
LPLSDVVISG VPGPKYKVDS SLLRDGCVCI NFSSEKNFDG PAIKEKASIY VPAIGKVTIA
VLLRNLLRLV QNQKAVAASA VGGSVEG
//
