ID S3E0Z8_GLAL2 Unreviewed; 946 AA.
AC S3E0Z8;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=DBL homology (DH-domain) {ECO:0000313|EMBL:EPE32188.1};
GN ORFNames=GLAREA_07321 {ECO:0000313|EMBL:EPE32188.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE32188.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE32188.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
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DR EMBL; KE145359; EPE32188.1; -; Genomic_DNA.
DR RefSeq; XP_008080200.1; XM_008082009.1.
DR AlphaFoldDB; S3E0Z8; -.
DR STRING; 1116229.S3E0Z8; -.
DR GeneID; 19466374; -.
DR KEGG; glz:GLAREA_07321; -.
DR eggNOG; KOG3519; Eukaryota.
DR HOGENOM; CLU_007879_0_0_1; -.
DR OMA; QPIYPRQ; -.
DR OrthoDB; 23973at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd05992; PB1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF15411; PH_10; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS51745; PB1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT DOMAIN 81..256
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 846..944
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT REGION 442..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 236..279
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 576..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 946 AA; 105755 MW; A70E0AFD2CD37CE3 CRC64;
MFQHAMSRFS VSSPDLQSEL AIQQTAVKNK FRRLKKNVRK QVTQVVNKVL DNSEARGLLV
ASTTNVPLTS APLPSGAQKS YRDYVVAELV DTERKYVQDL ENLHELKKKI EQKGVIPGDV
VHDIFLNINA ILDFQRRFLI KIETTNSQPD DQQAWGLPFT NYEESFNIYR PFIANQRKAA
DIAKRDFDKI VLADHPVVVD FNTLDGFLLK PMQRLVKYPM LLKDLRDKTN ADDATKEDLT
AGIEAANRVL KEANDAVDQE LLREAREDME SRVEDWKNHQ IEQFGDLLLY GHFPVVNGKS
DGQKEVRTLT SPLSSSNVQK FASLRLFRDS TTRKALDSTE RQNISSLEQS AEDAQSEALL
ALDQKSHGND QRQLTNDDTF LFNMLFDQFS GCDPETGAPI FAKRFADSMG ITAPTYEQYT
IYLFERILLC CKEINPNKSK DKVMGIQKDK KDKNKSKEPN KNAKLQLKGR IFMTNVTDVI
ALGKQGSYTV QIFWKGDPGV ENFIIRFSNE DAMKKWHAGV DGQRKLHAQA ISAGFSPEGG
PPTDFAWMRD QTAAMINPYA QHEDDDDEDD YRAQNSMYPG QMNQGMPRNG SSTSLRSRST
TSDSSQSLAG IARAPPPRFP MGFANQPLSI QTQINPAQSP GQRMGDSYFS PVAETPATSR
SSTQSNMFPF PRQGTPQGSW EEHNRYTAPA MPRAPSRGSQ TPSDAYGMNG RTPQRPSLPA
MASQSSQASA NLQRSRSHST PDINVQNGVR RLPNGAVSGP VPAVPGIPAH LHPAYDAGIP
RSQNNSPNGL PMRSNTQSPG TQRERMGTPT QYPNGPSHYS RSNISHRPDT SESRTMSPPL
GEAALPTQLK VKVNCDQQYI TLVVAFNITY QSLIDRIDAK IGRFSNNAIA KGTMRLRYRD
EDGDFVTIES DDDIQIAFQE WREAQKAQYH AGLLGEIELF CISVEN
//
