ID S3E1M6_GLAL2 Unreviewed; 1271 AA.
AC S3E1M6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=PX {ECO:0000313|EMBL:EPE32378.1};
GN ORFNames=GLAREA_07511 {ECO:0000313|EMBL:EPE32378.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE32378.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE32378.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; KE145359; EPE32378.1; -; Genomic_DNA.
DR RefSeq; XP_008080390.1; XM_008082199.1.
DR AlphaFoldDB; S3E1M6; -.
DR STRING; 1116229.S3E1M6; -.
DR GeneID; 19466564; -.
DR KEGG; glz:GLAREA_07511; -.
DR eggNOG; KOG2101; Eukaryota.
DR HOGENOM; CLU_002131_1_0_1; -.
DR OMA; AMYVVEV; -.
DR OrthoDB; 5392990at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06876; PX_MDM1p; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 67..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 137..326
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 451..590
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 917..1035
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 874..908
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 752..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1271 AA; 143107 MW; 8D63CA699AFAC98B CRC64;
MSTLLHKEAP PRACSVASST PPCRPRRTHS PATKIMALSR RDVILAGIAS FIAWGYAVNW
IPALRWAGYA LVVGIILPIV GLIALLVTTS RGSRYTYKNR QIRPKGPKFL GAKEWDKEIA
ALRRRQAYHW KPLYPESFLV SNALDELLEF ILRDFVSTWY SNISKNPVFV NEVDKTIRLA
LSSLLDIVLD LDITEIVTTR FVPILTAHFK EFYEAERAIR GKNLNRHVTE SDELDLAIAA
KYKDGKLHAA ASLAFSDLKL VQQDYLRKMT RELLPRLLPD RVLASRAVGV LIQELVSCAV
LSPAIGMLAE PDTWNQIMEA YGRSMLQDRS TVRKLRAALD EHASPAPKPK RTAPFPRISP
GDHERKFEKF VRAIRKVNNL SDARRFRSEI TSQLKRDALQ EGQDPIYLRR LDIGKRIADQ
RVHQLAAGGE RIPSADLSQK QAPVSKLENA SLVDLLRDPS GLSYFMEYMD RQSLMPMVQF
WIVVDGFRNP LEDESVEGDE IPVTLAPWTE ADRMDIAMIN EAYLSKPELK VSEQSKQHVT
DFLKAGKEAT PKQYFLARRA VLRTQTAALE SMQDKHLANF KKSDLFYKCL TSQEASKPQA
LQPSTIGPSR VETIYNKPAL PVRAISAQAL PPKPTPLSRV SAKLLPKRGH DLRRSVVSSN
DLVGATSRVS EILHENRPSF DEENSGPLFD DEDFDSEAMG NSIHSLDQDQ RESTPDNNVV
EAMEAALNDI MEDKPDVEEM RKSLFGQDLE SSIHSTSSLN GGHNSTRSSM DNKRVDLFGD
KVEKPSIASL GLVNTSSRIG VFTDDDLFGD EQKFLADEHD DPEEDKARDE EEEVHEAAPG
DLGLMEAITV LTADIDRLVA QDAVVDSLTR KAELTNNNAE LRILKKSKAS LQREIRRKEL
QRQQYVIQES DNSLYGRSTI KIKSIMAGKE EDGREYAVYV VEVQRKAGEQ MPAATWTVTR
RYSEFHELQQ RLRMKYSSVR NLDFPRRRMV MKMQSEFLSK RRQALEKYLR ELLLLPDVCR
SRELRAFLSQ SAIAPGTDSF YDHEDKKDIV TRFYNSVTDG MEDLLGNLPV LDQLSVAGQN
LLSAATNQLV TMPTAIGEDP VTAAEAEAEL NAFEDRELEP FVKPICDIFL EVFELNRGNN
WLRGRAVVVV LHQLLGGTIE RKVRDNVKGI ISEEAIIKYV GLLKDSMWPG GNLKRDGKPR
TEAEKAKSRT EASLMLATLI PDLAASVVGR VNAQAASRRI FATFNNPRLN AHLVFTMLDE
VIDVLFGDIR T
//
