ID S3EAT4_GLAL2 Unreviewed; 687 AA.
AC S3EAT4;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Multidrug resistance efflux transporter EmrE {ECO:0000313|EMBL:EPE35438.1};
GN ORFNames=GLAREA_11137 {ECO:0000313|EMBL:EPE35438.1};
OS Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE35438.1, ECO:0000313|Proteomes:UP000016922};
RN [1] {ECO:0000313|EMBL:EPE35438.1, ECO:0000313|Proteomes:UP000016922}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT the fungus Glarea lozoyensis.";
RL BMC Genomics 14:339-339(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KE145354; EPE35438.1; -; Genomic_DNA.
DR RefSeq; XP_008077517.1; XM_008079326.1.
DR AlphaFoldDB; S3EAT4; -.
DR GeneID; 19470179; -.
DR KEGG; glz:GLAREA_11137; -.
DR eggNOG; KOG2922; Eukaryota.
DR HOGENOM; CLU_012349_2_1_1; -.
DR OMA; HEIWGAI; -.
DR OrthoDB; 2906343at2759; -.
DR Proteomes; UP000016922; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF93; DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07070); 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016922};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 60..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 687 AA; 74499 MW; 10F2CE1768F69259 CRC64;
MPALSYIQPA TILGGGETQL QRWSSLIGIV TAIIGNILIS FALNIQRYAH IRLHDEKARR
KERAKSAAKG AQSGYGTIGR EGENARNPQN DEPANGDGED LLQSSFHSSG TDKSDNSTCS
KHDTTQVQTY LKSPYWWGGI ILMTVGEAGN FLAYGFAPAS IVSPLGVVAL ISNCVIAPIM
LKERFRFRDF CGVVVAVAGA VVVVLSAKTQ EKKFGPHEIW GAITNLEFEI YMSVTIFLIA
VLMWASPKYG NKTILIDLGL VGLFGGYTAL STKGVASMLS STLWRAFTTP VTYALIVILI
GTAVMQVRYV NKALQRFDST QVIPVQFVMF TLSVIIGSAI LYRDFEKATA DSVGKFVGGC
LLTFSGVYLI TSGRHSQDDE NDEDNESDEG GEERINLINH DPTDSETTQQ KRDFGSVQDS
NGLVQNGDGS YDDSESRRSS RVSFAGSSSR PRSPKMYSNS SRLPMSQSSG GSKDGKEIPR
LQNPWKTSNE ELSRHPGLPS SSSQPVLPTE AQTSLNDHLK PPPLGRPSSQ GNVHTHPNQQ
QHPTPPQPDR PATPVARHSI ARMLPGPFIS PLSGGLSVVV ADTLRRGVDS SRARRPKLGI
RRSKSGSQRL SHGARVESYY DETGTSPAKP IDPDNISKSL DSDGGTWSRV TRSRSLSNTL
GDLFRGKRQR LESRDGQGDE EAGPNGS
//
