ID   S3EE45_GLAL2            Unreviewed;      1060 AA.
AC   S3EE45;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=NAD(P)-binding Rossmann-fold containing protein {ECO:0000313|EMBL:EPE36543.1};
GN   ORFNames=GLAREA_08706 {ECO:0000313|EMBL:EPE36543.1};
OS   Glarea lozoyensis (strain ATCC 20868 / MF5171).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Helotiaceae; Glarea.
OX   NCBI_TaxID=1116229 {ECO:0000313|EMBL:EPE36543.1, ECO:0000313|Proteomes:UP000016922};
RN   [1] {ECO:0000313|EMBL:EPE36543.1, ECO:0000313|Proteomes:UP000016922}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 20868 / MF5171 {ECO:0000313|Proteomes:UP000016922};
RX   PubMed=23688303; DOI=10.1186/1471-2164-14-339;
RA   Chen L., Yue Q., Zhang X., Xiang M., Wang C., Li S., Che Y.,
RA   Ortiz-Lopez F.J., Bills G.F., Liu X., An Z.;
RT   "Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in
RT   the fungus Glarea lozoyensis.";
RL   BMC Genomics 14:339-339(2013).
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DR   EMBL; KE145352; EPE36543.1; -; Genomic_DNA.
DR   RefSeq; XP_008075858.1; XM_008077667.1.
DR   AlphaFoldDB; S3EE45; -.
DR   STRING; 1116229.S3EE45; -.
DR   GeneID; 19467754; -.
DR   KEGG; glz:GLAREA_08706; -.
DR   eggNOG; KOG1178; Eukaryota.
DR   HOGENOM; CLU_002220_0_0_1; -.
DR   OrthoDB; 2230730at2759; -.
DR   Proteomes; UP000016922; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43439:SF2; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR   PANTHER; PTHR43439; PHENYLACETATE-COENZYME A LIGASE; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016922}.
FT   DOMAIN          669..877
FT                   /note="Thioester reductase (TE)"
FT                   /evidence="ECO:0000259|Pfam:PF07993"
SQ   SEQUENCE   1060 AA;  119426 MW;  5F672597B1167123 CRC64;
     MLFKRLPSED SQEPRLLPNL IDEIALHDPS RIFAIIPGFQ DPNDFIHITF RDLAKAIDRT
     AWWMKETFDH GGSSKVLVYV GSCDILYHIV IVAAAKLEFE TFLPSPENPD EMFPQLYLAS
     KWSQLVVSER FAEEHNIRAN NGGFGRFVTL SPSLEYILRA RNISRPAQFT LTSQFEEVAN
     SPFVAFQLKD GQFVKANHSW TCSFDPCYPN AGLEGKNTVY EDFIGRRVVN AIPPYHIVGF
     IIGLLYPVYY GTHTVWFHAD APVTCTQIET MLSRIPADTT FMEPSMLQGA ACYSCFQQKL
     GQQAAVLPGG SVPSTLRSQL FSSIWLAHMV HTILLKDEIL TSNDWQFFQF PFTHLQPHQA
     TFSELWRCDI NGCPRKIETV NDDSANYPAT ESDVAFYMEV EKVSQSFNHD STLTGIVLPR
     HDKVKRMVII TKEELAPRAF IILRGQFAAS DSTNAEKIQH YLQILEKLRP TLALVTKNYN
     LPVPIPDENI IFTSEDECSL DADDREIVQQ FADHINMMER MPLIADDMMN RSSALENEEY
     LISYIQMAIE TITKLGKRCQ VDFDIFGAGG LGWKQLVKLV AFLKAVLADE DASLITPKLI
     FESRTPTNLA RSVKRISEEW FAAQRVFKTG ASLFDVLENY FDRLSEMKHD PNRNKGSPPA
     EEGGLVVMLT GSTRSLGSYM LDALLSRPNN HFRKVYCINT SRGRSAALRY RTAANNLPAH
     QNGGDRLFFQ QADLSLRRFG LSSTLYKELQ DSVQVVIHTS WKEDLNAGLA AFKTSLDGLL
     NLIRFSTESR HRPIICFASS TRSVGCYRTL PGNFAPECQI ADAEAPTKDG YGQSKWIGEQ
     MLSAASENCD VRSVIWRIGE LAGPVNQQGE WPKEGWRGSL ITSSKYLRAV PTFGWIHLFY
     LIPIDVLASI LVEICENVYP ELVSNSNDYM KAKYYNVRNP EDMAWETHIV PAVMRVLKSN
     GIEDMQNMRW GEWLELLEAS QGNDGENPAF DLLNFYKNVE IGGGVGCLAL HKECAFEKSA
     ILRGLDGTNQ VRWLGIWLQQ LGIIPTAPGA IIQGTAGVEF
//