ID S3IGT2_9ENTR Unreviewed; 348 AA.
AC S3IGT2;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=ECA polysaccharide chain length modulation protein {ECO:0000256|HAMAP-Rule:MF_02025};
GN Name=wzzE {ECO:0000256|HAMAP-Rule:MF_02025};
GN ORFNames=HMPREF0201_04821 {ECO:0000313|EMBL:EPF12235.1};
OS Cedecea davisae DSM 4568.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Cedecea.
OX NCBI_TaxID=566551 {ECO:0000313|EMBL:EPF12235.1, ECO:0000313|Proteomes:UP000014585};
RN [1] {ECO:0000313|EMBL:EPF12235.1, ECO:0000313|Proteomes:UP000014585}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4568 {ECO:0000313|EMBL:EPF12235.1,
RC ECO:0000313|Proteomes:UP000014585};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Palsikar V.B., Zhang X., Suruliraj S., Perna N.T., Plunkett G.,
RA Warren W., Mitreva M., Mardis E.R., Wilson R.K.;
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Modulates the polysaccharide chain length of enterobacterial
CC common antigen (ECA). {ECO:0000256|HAMAP-Rule:MF_02025}.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC antigen biosynthesis. {ECO:0000256|HAMAP-Rule:MF_02025}.
CC -!- SUBUNIT: Probably part of a complex composed of WzxE, WzyE and WzzE.
CC {ECO:0000256|HAMAP-Rule:MF_02025}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_02025}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_02025}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WzzB/Cld/Rol family. {ECO:0000256|HAMAP-
CC Rule:MF_02025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPF12235.1}.
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DR EMBL; ATDT01000042; EPF12235.1; -; Genomic_DNA.
DR RefSeq; WP_016538972.1; NZ_KE161030.1.
DR AlphaFoldDB; S3IGT2; -.
DR STRING; 566551.HMPREF0201_04821; -.
DR PATRIC; fig|566551.4.peg.4414; -.
DR HOGENOM; CLU_060925_2_1_6; -.
DR OrthoDB; 9775724at2; -.
DR UniPathway; UPA00566; -.
DR Proteomes; UP000014585; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1890.10; FepE-like; 1.
DR HAMAP; MF_02025; WzzE; 1.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR032895; WzzE.
DR PANTHER; PTHR32309:SF16; ECA POLYSACCHARIDE CHAIN LENGTH MODULATION PROTEIN; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF160355; Bacterial polysaccharide co-polymerase-like; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02025};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_02025};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02025};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_02025};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_02025}.
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02025"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02025"
FT DOMAIN 14..81
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
SQ SEQUENCE 348 AA; 39199 MW; 752017F7AC1A0D24 CRC64;
MKENVPGSNP AVDNELDIRG LFRTLWQGKF WIVGIAFIFA IIALTYTFLA KQEWSATAIT
DRPTVNMLGG YYSQQQFLRN LDIKSDMAST DRPSAMDEAY KEFIVQLSAY DTRRDFWLQT
DYYKQRQVGN SKADAALLDE ITDNIQFTSG DAARNISDSV KLTAETAADA NNLLRQYVAF
ASQRAASHLN EELTGAWAAR TTQMKAQVKR QEAVAQAIYD RKMKSIEQAL KIAQQQNITR
SETNVPADEL PDSEMFMLGR PMLQARLESL QAVGPDFDID YDQNRAMLNT LNVGPTVDAR
FQTYRYLRTP EEPVKRDSPR RAFLLIMWGA VGALIGAGVA LARRPKIA
//
