ID S3J8H5_9ENTR Unreviewed; 377 AA.
AC S3J8H5;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Thiazole biosynthesis protein ThiH {ECO:0000313|EMBL:EPF20966.1};
GN ORFNames=HMPREF0201_00023 {ECO:0000313|EMBL:EPF20966.1};
OS Cedecea davisae DSM 4568.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Cedecea.
OX NCBI_TaxID=566551 {ECO:0000313|EMBL:EPF20966.1, ECO:0000313|Proteomes:UP000014585};
RN [1] {ECO:0000313|EMBL:EPF20966.1, ECO:0000313|Proteomes:UP000014585}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 4568 {ECO:0000313|EMBL:EPF20966.1,
RC ECO:0000313|Proteomes:UP000014585};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Palsikar V.B., Zhang X., Suruliraj S., Perna N.T., Plunkett G.,
RA Warren W., Mitreva M., Mardis E.R., Wilson R.K.;
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPF20966.1}.
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DR EMBL; ATDT01000002; EPF20966.1; -; Genomic_DNA.
DR RefSeq; WP_016517386.1; NZ_KE161030.1.
DR AlphaFoldDB; S3J8H5; -.
DR STRING; 566551.HMPREF0201_00023; -.
DR PATRIC; fig|566551.4.peg.16; -.
DR HOGENOM; CLU_046249_1_0_6; -.
DR OrthoDB; 9801120at2; -.
DR Proteomes; UP000014585; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR012726; ThiH.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR02351; thiH; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF1; 2-IMINOACETATE SYNTHASE; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00301; 2-iminoacetate_synthase_(ThiH); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 72..302
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 327..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 43151 MW; 93924EBC60B6D93F CRC64;
MTETFSDRWR QLDWDDINLR INSKTSADVE RALAAPRLTQ DNLMALLSPA ASRYLEPLAR
RAQQLTRQRF GNTVSFYVPL YLSNLCANDC TYCGFSMSNK LKRKTLDEAE IERECAAIRA
LGFEHLLLVT GEHQTKVGMN YFRQHLPAIR SRFSSLQMEV QPLDEHEYAE LKTLGLDGVM
VYQETYHPAT YAQHHLRGNK QDFFWRLETP DRLGRAGIDK IGLGALIGLS DSWRTDCFMV
AEHLLWLQQR YWQTRYSISF PRLRPCTGGV EPASIMTEQQ LVQVICAFRL LAPDVELSLS
TRESPWFRDH VIPLAINNVS AFSKTQPGGY ADNHPELEQF SPHDGRTPQE VAAALRDSGL
QPVWKDWDSF LGRGTQP
//
