ID   S3L4B2_TREMA            Unreviewed;       793 AA.
AC   S3L4B2;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN   ORFNames=HMPREF9194_01975 {ECO:0000313|EMBL:EPF31624.1};
OS   Treponema maltophilum ATCC 51939.
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=1125699 {ECO:0000313|EMBL:EPF31624.1, ECO:0000313|Proteomes:UP000014541};
RN   [1] {ECO:0000313|EMBL:EPF31624.1, ECO:0000313|Proteomes:UP000014541}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51939 {ECO:0000313|EMBL:EPF31624.1,
RC   ECO:0000313|Proteomes:UP000014541};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Leonetti C., Blanton J.M.,
RA   Dewhirst F.E., Izard J., Walker B., Young S., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Treponema maltophilum ATCC 51939.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPF31624.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ATFF01000006; EPF31624.1; -; Genomic_DNA.
DR   RefSeq; WP_016526233.1; NZ_KE332518.1.
DR   AlphaFoldDB; S3L4B2; -.
DR   STRING; 1125699.HMPREF9194_01975; -.
DR   PATRIC; fig|1125699.3.peg.1996; -.
DR   eggNOG; COG1752; Bacteria.
DR   HOGENOM; CLU_014750_1_0_12; -.
DR   OrthoDB; 9770965at2; -.
DR   Proteomes; UP000014541; Unassembled WGS sequence.
DR   GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07205; Pat_PNPLA6_PNPLA7_NTE1_like; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR000184; Bac_surfAg_D15.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   PANTHER; PTHR14226:SF82; PATATIN-LIKE PROTEIN, PLPD; 1.
DR   Pfam; PF01103; Omp85; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014541};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..793
FT                   /note="PNPLA domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004523135"
FT   DOMAIN          35..226
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          327..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        328..347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   793 AA;  86694 MW;  4024249F94CAB1CC CRC64;
     MKFKQKMTAA AAVLLCCCVV FSAAETPKTR PSVALVLAGG GARGFVHIPF LELIDELGIP
     IDMIVGTSAG AIIGGLYCAG YTPQEIKDSV LYLDWVDIFR NDNFSPFEHA LNEHGLPANP
     IALKLGANLS LNLGKGLLTG QKAYEQLKSL TIKIPSYIDF DSLSVPFRAA ATDLLTGKLA
     IFEQGDLAEA MRASMSIPGL FEPFPVDGRY YIDGSASDNL PIRTAKELGF DIIIAVEISN
     PLRTNADDFD SSPLKVLEQM VSMQQAIKGK EDYAMTDLVM FPDIRDFSTI DYLRAEDIYK
     RGKVEAERYR GSLIELKKKI FPLQDAAPSS LTEKNPPEEN PQSAQNGKID GFRFIETQET
     VSLHKGTYAG LPYARPSELI LKGCKDSDKH YFERIFAAAA DKPFTEQVLV NLTDAAMNTG
     NYTSAVSRID ARGDKNILEL SLQKKPEENG LILQSLTFAG TASSASSGAL TLSTAAQFRG
     LGGTGSVISL RVSYVNNTAF DFLFFQPLGP KVFFQTKASV SHEPDFFSSN FDFHAVNGSL
     IRRASLKAGA GILFNPYHTL VNEGALRWLD TRQAIPYDTA WPFAPYDKNL YDFTADISSL
     YTFSNLNFRS FPTKGFFSST EAQAVFPLGQ RYDVRIFDRI KTDFTAALPV SQHLTVLCSL
     FAGSCLSEQL KKAPSLIPVY GFNLKERLFF PHVTAARKYG IHKAAASLAL QIQPWQQLTI
     LGGQLFFSLT GSVGDVWPDF ASFAQSPDLT WRVSAGTGVR IKGLFSVRLC AGAGSSDGKI
     SPFASCDYGI ALY
//