ID S3MQ00_9GAMM Unreviewed; 553 AA.
AC S3MQ00;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=L-lactate permease {ECO:0000256|ARBA:ARBA00039210, ECO:0000256|RuleBase:RU365092};
GN ORFNames=F945_03569 {ECO:0000313|EMBL:EPF70005.1};
OS Acinetobacter rudis CIP 110305.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=421052 {ECO:0000313|EMBL:EPF70005.1, ECO:0000313|Proteomes:UP000014568};
RN [1] {ECO:0000313|EMBL:EPF70005.1, ECO:0000313|Proteomes:UP000014568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 110305 {ECO:0000313|EMBL:EPF70005.1,
RC ECO:0000313|Proteomes:UP000014568};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cerqueira G., Feldgarden M., Courvalin P., Perichon B.,
RA Grillot-Courvalin C., Clermont D., Rocha E., Yoon E.-J., Nemec A.,
RA Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Acinetobacter rudis CIP 110305.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU365092}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPF70005.1}.
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DR EMBL; ATGI01000039; EPF70005.1; -; Genomic_DNA.
DR AlphaFoldDB; S3MQ00; -.
DR STRING; 632955.GCA_000829675_02625; -.
DR PATRIC; fig|421052.3.peg.3500; -.
DR eggNOG; COG1620; Bacteria.
DR HOGENOM; CLU_021628_0_0_6; -.
DR OrthoDB; 9761056at2; -.
DR Proteomes; UP000014568; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR NCBIfam; TIGR00795; lctP; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR PANTHER; PTHR30003:SF10; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519,
KW ECO:0000256|RuleBase:RU365092};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Reference proteome {ECO:0000313|Proteomes:UP000014568};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 15..36
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 42..61
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 73..92
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 119..148
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 155..180
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 200..218
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 253..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 304..320
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 370..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 409..437
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 443..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 531..552
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
SQ SEQUENCE 553 AA; 59976 MW; 6C7136466B576571 CRC64;
MLQQWQQIYD PMDNIWFSSL ISLIPIVFFF LALAVFRMKG SVAGSITVLL ALLVALFAYG
MPTSMAFSSL AYGFFYGLWP IAWIILGALF LYKVSVKTGQ FEIIRASILS LTHDQRLQML
LVGFAFGTFL EGAAGFGAPV AITAALLVGL GFKPLYAAGL CLIANTAPVA FGAMGIPIIV
AGQVSGVDTM EISQMVGRQL PFMVPIVLFW IMAIMDGWRG VKETWPAVVV AGGSFAIAQY
LTSNFLGPEL PDITAAIASI ICLSILLKFW QPKHIFRFDQ TEAAVNAEAE TSNKKYTIAQ
IAKAWSPFAI LTVMVTIWSI KPFKDLFAKG GALQDWVISI EVPFLHQMIQ KMPPVVNQIK
DYDAIYKFDW FSATGTAIIL AAVITIIYLK MQPREAVKTF VETAKELRVP VYSIGMVLSF
AFIANYSGMS ATLALALAHS GDAFTFFSPF LGWLGVFLTG SDTSANALFS ALQATTAQQI
GVPEVLLVAA NTSGGVTGKM ISPQSIAIAC AAVGLVGKES DLFRFTVKHS LIFTVMIGII
VTLQAYVLPW MIP
//
