ID S3VG19_9LEPT Unreviewed; 586 AA.
AC S3VG19;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Phospholipase, patatin family {ECO:0000313|EMBL:EPG75425.1};
GN ORFNames=LEP1GSC058_2287 {ECO:0000313|EMBL:EPG75425.1};
OS Leptospira fainei serovar Hurstbridge str. BUT 6.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1193011 {ECO:0000313|EMBL:EPG75425.1, ECO:0000313|Proteomes:UP000014540};
RN [1] {ECO:0000313|EMBL:EPG75425.1, ECO:0000313|Proteomes:UP000014540}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BUT 6 {ECO:0000313|EMBL:EPG75425.1,
RC ECO:0000313|Proteomes:UP000014540};
RA Harkins D.M., Durkin A.S., Selengut J.D., Sanka R., DePew J., Purushe J.,
RA Ahmed A., van der Linden H., Goris M.G.A., Hartskeerl R.A., Vinetz J.M.,
RA Sutton G.G., Nelson W.C., Fouts D.E.;
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPG75425.1}.
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DR EMBL; AKWZ02000003; EPG75425.1; -; Genomic_DNA.
DR RefSeq; WP_016548513.1; NZ_AKWZ02000003.1.
DR AlphaFoldDB; S3VG19; -.
DR STRING; 1193011.LEP1GSC058_2287; -.
DR OrthoDB; 9770965at2; -.
DR Proteomes; UP000014540; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProt.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd07205; Pat_PNPLA6_PNPLA7_NTE1_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF82; PATATIN-LIKE PROTEIN, PLPD; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF01734; Patatin; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}.
FT DOMAIN 18..117
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 308..468
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 586 AA; 67004 MW; 00A1A3BAD2EB54BD CRC64;
MIRFVPPEAL QFLASIPLFK SLPRKFLVQI YKHIEERNIY NHDVIYYKGE ISKELYLIRH
GEVMVTLGEA GQTVRYLGEG DIFAENSVLT RSVHSGSATA VLDTLLYVLD GEYFLRLAAK
EKILSQNLMR LMGIRMREVI EGVIKNPSVP RRLICHIPTE EIEDFKHHLD SIVETGRRSH
EGNVSLFKID TFKDKSLSDM IRMISQLRKK SPVLHIYFRT PSIMPEFDKV VQQCDQIVFW
EDNPERNVKQ KTEIIDYWKP RIRNYDGRTS KIVVSDKAIH HEDKSTNQRI FYKGETFARY
LVSKTRGLAL GGGGARALAH VGLLKVLERE GIRFDYVSGS SFGAVIAALY ARGESADSIY
KMISKFFGGI DKPFDPTIPL ISFFKGKKML RMLKDAFGSQ LIEDLKIPFV TSAVDLHSGQ
EYVMDQGPIW EALASAMSLP GMFPPVFKGD HLLIDGGVIN NVPDNLIRKR GADVILSVNV
SPLRDDAIVR LLEDRKVTGK SFFKNLWEDV TYPPILKIMA RAITLEGREI TKLRKEKMDL
FVNMHIEEFA FTDFGRYKEV IKKGELEAEA ATKEIRELFF PSERKK
//
