ID S3ZP79_9ACTN Unreviewed; 462 AA.
AC S3ZP79;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Putative DNA polymerase IV {ECO:0000313|EMBL:EPH40145.1};
GN ORFNames=STRAU_6795 {ECO:0000313|EMBL:EPH40145.1};
OS Streptomyces aurantiacus JA 4570.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=1286094 {ECO:0000313|EMBL:EPH40145.1, ECO:0000313|Proteomes:UP000014629};
RN [1] {ECO:0000313|EMBL:EPH40145.1, ECO:0000313|Proteomes:UP000014629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA 4570 {ECO:0000313|EMBL:EPH40145.1,
RC ECO:0000313|Proteomes:UP000014629};
RA Gruening B.A., Praeg A., Erxleben A., Guenther S., Mueller M.;
RT "Draft Genome Sequence of Streptomyces aurantiacus, Which Produces
RT Setomimycin.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPH40145.1}.
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DR EMBL; AOPZ01000442; EPH40145.1; -; Genomic_DNA.
DR AlphaFoldDB; S3ZP79; -.
DR PATRIC; fig|1286094.4.peg.6718; -.
DR Proteomes; UP000014629; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProt.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014629}.
FT DOMAIN 33..136
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 303..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 48138 MW; 9682A5C8C7E19C2B CRC64;
MAPESGERGM STLYVRFLTS GPEGAPGEAL LPQLLAVVGE FTPVVEALPP DAALADVSGA
RRYFGRDAAG IAALIRVRTL ALYGVDCLIG AGPGPMLARM AARDAAPGVT RVVPGSPDAV
AEFLDGRPVA ELPGVGRAGA RTLCEYGLDT VGRVAAAPLS TLQRLVGARA GRELYDRAHG
VDRARVAPNA ATRSLAVERP FPRDEIDPHR HRRALLSGAE ELGVRLRGDA QVCRSLTLTV
RYADRSVTTR TRALPEPTAH AAALTAAAYR MYEALGLQRA RVRALALRAE GIAPAALAAR
QLTFDPADEK ARRRRREGPP HRGGGRPGPG EVRPGGDRAG DAGGRVRDAG ARAGDAAQVV
APPRRGGQAP GLIIAVRLGP SPARAVQTAP APPALRRKTS PCPRSAPAPS VTSPTSRTPT
GSNPSPGSRR GRGTTKPRTS TGATSRNWTA AARCSPSRRS PR
//
