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Database: UniProt
Entry: S40A2_ARATH
LinkDB: S40A2_ARATH
Original site: S40A2_ARATH 
ID   S40A2_ARATH             Reviewed;         512 AA.
AC   F4KGN5; Q9LZC8;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 68.
DE   RecName: Full=Solute carrier family 40 member 2;
DE   AltName: Full=Ferroportin-2;
DE   AltName: Full=Iron-regulated transporter 2;
DE            Short=AtIREG2;
GN   Name=IREG2; Synonyms=FPN2; OrderedLocusNames=At5g03570; ORFNames=F12E4.370;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14993207; DOI=10.1101/gr.1515604;
RA   Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA   Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA   Weissenbach J., Salanoubat M.;
RT   "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT   combined approach to evaluate and improve Arabidopsis genome annotation.";
RL   Genome Res. 14:406-413(2004).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=16790430; DOI=10.1074/jbc.m601062200;
RA   Schaaf G., Honsbein A., Meda A.R., Kirchner S., Wipf D., von Wiren N.;
RT   "AtIREG2 encodes a tonoplast transport protein involved in iron-dependent
RT   nickel detoxification in Arabidopsis thaliana roots.";
RL   J. Biol. Chem. 281:25532-25540(2006).
CC   -!- FUNCTION: Vacuolar transporter that is involved in the transport of
CC       excess nickel into the vacuole under iron deficiency, increasing
CC       cellular tolerance to nickel under iron deficiency stress response.
CC       {ECO:0000269|PubMed:16790430}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000305|PubMed:16790430};
CC       Multi-pass membrane protein {ECO:0000305|PubMed:16790430}.
CC       Note=Tonoplast.
CC   -!- INDUCTION: By iron deficiency in roots. {ECO:0000269|PubMed:16790430}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC       conditions, but plants have increased sensitivity to nickel when grown
CC       in an iron-deficient environment. {ECO:0000269|PubMed:16790430}.
CC   -!- MISCELLANEOUS: Plants over-expressing IREG2 show increased tolerance to
CC       elevated concentrations of nickel. {ECO:0000305|PubMed:16790430}.
CC   -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BX832179; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC       Sequence=CAB83320.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL162751; CAB83320.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED90628.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED90629.1; -; Genomic_DNA.
DR   EMBL; BX832179; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; T48385; T48385.
DR   RefSeq; NP_001190217.1; NM_001203288.1.
DR   RefSeq; NP_195977.2; NM_120438.4.
DR   AlphaFoldDB; F4KGN5; -.
DR   SMR; F4KGN5; -.
DR   BioGRID; 17063; 1.
DR   STRING; 3702.F4KGN5; -.
DR   PaxDb; 3702-AT5G03570-2; -.
DR   EnsemblPlants; AT5G03570.1; AT5G03570.1; AT5G03570.
DR   EnsemblPlants; AT5G03570.2; AT5G03570.2; AT5G03570.
DR   GeneID; 831787; -.
DR   Gramene; AT5G03570.1; AT5G03570.1; AT5G03570.
DR   Gramene; AT5G03570.2; AT5G03570.2; AT5G03570.
DR   KEGG; ath:AT5G03570; -.
DR   Araport; AT5G03570; -.
DR   TAIR; AT5G03570; IREG2.
DR   eggNOG; KOG2601; Eukaryota.
DR   HOGENOM; CLU_020370_1_0_1; -.
DR   InParanoid; F4KGN5; -.
DR   OMA; YPVFISY; -.
DR   PRO; PR:F4KGN5; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4KGN5; baseline and differential.
DR   Genevisible; F4KGN5; AT.
DR   GO; GO:0009705; C:plant-type vacuole membrane; IDA:UniProtKB.
DR   GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IMP:TAIR.
DR   GO; GO:0005381; F:iron ion transmembrane transporter activity; IMP:TAIR.
DR   GO; GO:0010106; P:cellular response to iron ion starvation; IMP:UniProtKB.
DR   GO; GO:0055068; P:cobalt ion homeostasis; IMP:TAIR.
DR   GO; GO:0006824; P:cobalt ion transport; IMP:TAIR.
DR   GO; GO:0006826; P:iron ion transport; IMP:TAIR.
DR   GO; GO:0035444; P:nickel cation transmembrane transport; IMP:UniProtKB.
DR   GO; GO:0015675; P:nickel cation transport; IMP:TAIR.
DR   GO; GO:0000041; P:transition metal ion transport; IMP:TAIR.
DR   CDD; cd17480; MFS_SLC40A1_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR009716; Ferroportin-1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR   PANTHER; PTHR11660:SF57; SOLUTE CARRIER FAMILY 40 PROTEIN; 1.
DR   Pfam; PF06963; FPN1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Nickel; Nickel transport; Reference proteome;
KW   Stress response; Transmembrane; Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..512
FT                   /note="Solute carrier family 40 member 2"
FT                   /id="PRO_0000415899"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        442..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  57094 MW;  F07AA5425B4500F7 CRC64;
     MEEETETRVF LSNEQHQEEE EEEEEEPSLP RSMVISLYLG YFLARWGART WEFSVALYMI
     YLWPNSLFLT AMYGVVESGS ATLFGPIVGQ MIDGMSYVKV LRLWLVTQNL SFIVAGGAVV
     ALLVVPDLKS QNFPVFATLV VLTNLSGAIG VLSTLAGTVL IERDWVVVMS EGHSPAVLTR
     MNSVIRGIDL SSKLLSPVIT GLIISFVSLR ASAITFAAWA TITVWIEYWL FISVYNGVPA
     IVQSDERRSL RSSQSQAEET DSASSFYVPL LHEEESYRNT QSRSRILRIL ERISESSFVS
     AWRNYLNQEI VLPGVSLALL FFTVLSFGTL MTATLEWKGI PTYIIGIGRG ISAGVGLAAT
     VLYPLMQSRI SPLRTGVWSF WSQWTCLLVC VGSIWVEKEK IASYMLMAGV AASRLGLWMF
     DLAVIQQMQD LVPESDRCVV GGVQNSLQSA LDLMANLLGI IVSNPKDFWM LTLISFATVS
     LAGILYTIHL YRIRKHLFHL EKIPLLNNFF AS
//
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