GenomeNet

Database: UniProt
Entry: S4A1A7_9ACTN
LinkDB: S4A1A7_9ACTN
Original site: S4A1A7_9ACTN 
ID   S4A1A7_9ACTN            Unreviewed;      1205 AA.
AC   S4A1A7;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   11-DEC-2019, entry version 37.
DE   SubName: Full=Putative ATP-dependent DNA helicase UvrD1 {ECO:0000313|EMBL:EPH44465.1};
GN   ORFNames=STRAU_2482 {ECO:0000313|EMBL:EPH44465.1};
OS   Streptomyces aurantiacus JA 4570.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1286094 {ECO:0000313|EMBL:EPH44465.1, ECO:0000313|Proteomes:UP000014629};
RN   [1] {ECO:0000313|EMBL:EPH44465.1, ECO:0000313|Proteomes:UP000014629}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JA 4570 {ECO:0000313|EMBL:EPH44465.1,
RC   ECO:0000313|Proteomes:UP000014629};
RA   Gruening B.A., Praeg A., Erxleben A., Guenther S., Mueller M.;
RT   "Draft Genome Sequence of Streptomyces aurantiacus, Which Produces
RT   Setomimycin.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01129065};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS01099290};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|SAAS:SAAS00709641}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPH44465.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AOPZ01000097; EPH44465.1; -; Genomic_DNA.
DR   EnsemblBacteria; EPH44465; EPH44465; STRAU_2482.
DR   PATRIC; fig|1286094.4.peg.2455; -.
DR   BioCyc; GCF_000414115:G1EG3-2479-MONOMER; -.
DR   Proteomes; UP000014629; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00146071};
KW   DNA damage {ECO:0000256|SAAS:SAAS01099294};
KW   DNA repair {ECO:0000256|SAAS:SAAS01099287};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00745286};
KW   Exonuclease {ECO:0000256|SAAS:SAAS01033115};
KW   Helicase {ECO:0000256|SAAS:SAAS00553650, ECO:0000313|EMBL:EPH44465.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00146062};
KW   Nuclease {ECO:0000256|SAAS:SAAS01033141};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00145996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014629}.
FT   DOMAIN          17..344
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          345..664
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          838..880
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          904..931
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1167..1205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        853..872
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1191..1205
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1205 AA;  129574 MW;  94E0021ED9CB1753 CRC64;
     MSPRLTDPEQ LKELLGIPFT PEQTACITAP PAPQVIVAGA GSGKTTVMAA RVVWLVGTGQ
     VAPEQVLGLT FTNKAAGELA ERVRKALIKA GVTDPDAADP DNPPGEPVIS TYHAFAGRLL
     TDHGLRIGLE PTARLLADAT RFQLAARVLR EAPGPYPALT RSFPDLVSDL LALDSELAEH
     LVAPGRLRAY DAELLRSLAG AKLTNADLRK VPETAAARTE LTGLVERYRD AKRARDLLDF
     GDQIAHSATL ARTRAEVGAV LREEFRVVLL DEYQDTSVAQ RVLLAGLFGG GTGHPVTAVG
     DPCQAIYGWR GASVANLDDF PDHFAGADGR PATRHALSEN RRSGGRLLDL ANGLAEPLRA
     LHAGVEALRP APGAERDGSV RCALLRTHGE EIAWIADSIA HLVATGKAPG EIAVLCRTAT
     DFAEIQGALV ARDVPVEVVG LSGLLHLPEV ADLVAVCEVL QDPGANASLV RLLTGPRWRV
     GPRDLALLGR RARLLVRHGH SAPEDPDRRL AEAVEGVDPS EVISLADALD TFLEAPADAS
     GDGDDGLPFS AEARVRFARL ATELRDLRRS LADPLMDVLH RVLAVTGLEV ELSASPHALA
     ARRRETLSNF LDVAASFAAN DPSASLLAFL GFLRTAAQYE KGLDNALPGG ENTVKVLTAH
     KSKGLEWDVV AVPGLVTGTF PSAQGREKWT AQAKVVPHAL RGDADTLPDI DAWDAKGMKA
     FHADMKDHQH TEELRLGYVT FTRPRSLLLG SGHWWGPTQK KPRGPSDFLR ALYDHCAAGH
     GEIEAWADEP AEDEENPALH EKTADQVWPL PLDAASLARR RAAADTVLAH LDRLAADDAR
     SHEEAHPAAG APAPAYAPEP PEYAADPDWP PPPDDEALAE EGAYGDGAYE GDTYEDGCYV
     DDVHEDARPS EGADPTAWDS WTRERPAPHA RVPHTRAHLT PEETRTLASW DRDLDALTGE
     LLRARESVRD VPLPATLTAS QVLRLAGDPD GLAQELARPM PQPPQPAARR GTRFHAWVEA
     RFEELRLPML GPDELPGGGP GEAEIADERD LEALKEAFER TEYAHRTPYR VEAPFQLAIA
     GRVIRGRMDA VYKNGDGDDT TYEIVDWKTG RTQNADPLQL AVYRLAWADQ HGVPPESVRV
     AFLYVRSGET VRPTDLPGRA ELERILLGED GQEAPGAADA GGAGREAAGG QRTDRPPDRT
     ARAGR
//
DBGET integrated database retrieval system