ID S4A704_9ACTN Unreviewed; 580 AA.
AC S4A704;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Putative Pyruvate dehydrogenase {ECO:0000313|EMBL:EPH46545.1};
GN ORFNames=STRAU_0517 {ECO:0000313|EMBL:EPH46545.1};
OS Streptomyces aurantiacus JA 4570.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=1286094 {ECO:0000313|EMBL:EPH46545.1, ECO:0000313|Proteomes:UP000014629};
RN [1] {ECO:0000313|EMBL:EPH46545.1, ECO:0000313|Proteomes:UP000014629}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA 4570 {ECO:0000313|EMBL:EPH46545.1,
RC ECO:0000313|Proteomes:UP000014629};
RA Gruening B.A., Praeg A., Erxleben A., Guenther S., Mueller M.;
RT "Draft Genome Sequence of Streptomyces aurantiacus, Which Produces
RT Setomimycin.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPH46545.1}.
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DR EMBL; AOPZ01000017; EPH46545.1; -; Genomic_DNA.
DR RefSeq; WP_016638651.1; NZ_AOPZ01000017.1.
DR AlphaFoldDB; S4A704; -.
DR PATRIC; fig|1286094.4.peg.503; -.
DR OrthoDB; 4959782at2; -.
DR Proteomes; UP000014629; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Pyruvate {ECO:0000313|EMBL:EPH46545.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000014629};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 5..120
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 192..320
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 383..529
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 580 AA; 62318 MW; A1F371F5EF345F5D CRC64;
MAKQNVAEQF VDILVRAGVK RLYGVVGDSL NPVVDAIRRT KAIDWIQVRH EETAAFAAGA
EAQITGSLAA CAGSCGPGNL HLINGLYDAH RSMAPVLALA SQIPSSEIGL GYFQETHPDQ
LFRECSHYSE LIASPKQMPR LLQTAIQHAV GQSGVSVVSL PGDVASEAAP EKAAETALVT
SRPSVRPGDA EIDKLAAMID EADKVTLFCG SGTAGAHAEV MAFAEKIKSP VGHALRGKEW
IQYDNPYDVG MSGLLGYGAA YEATHECDLL ILLGTDFPYN AFLPDDVKIA QVDVRPEHLG
RRSRLDLAVW GDVRETLRCL TPRVSPKSNR KFLDKMLKKH ADALEGVVKA YTRKVEKHIP
IHPEYVASVL DDLADPSAIF TVDTGMCNVW AARYISPNGK RRIIGSFSHG SMANALPQAI
GAQFTDRKRQ VISMSGDGGF TMLMGDFLTL VQYDLPVKVV LFNNSSLGMV ELEMLVAGLP
SYGTTNHNPD FAAVARAAGA YGVRVEKPKQ LASALKDAFS HKGPALVDIV TDPNALSIPP
KISSEMVTGF ALSASKIVLD GGVGRMLQMA RSNLRNVPRP
//
