ID S4MKW1_9ACTN Unreviewed; 706 AA.
AC S4MKW1;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=STAFG_8813 {ECO:0000313|EMBL:EPJ34102.1};
OS Streptomyces afghaniensis 772.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1283301 {ECO:0000313|EMBL:EPJ34102.1, ECO:0000313|Proteomes:UP000015001};
RN [1] {ECO:0000313|EMBL:EPJ34102.1, ECO:0000313|Proteomes:UP000015001}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=772 {ECO:0000313|EMBL:EPJ34102.1,
RC ECO:0000313|Proteomes:UP000015001};
RA Gruening B.A., Praeg A., Erxleben A., Guenther S., Fiedler H.-P.,
RA Goodfellow M., Mueller M.;
RT "Draft Genome Sequence of Streptomyces afghaniensis, Which Produces
RT Compounds of the Julimycin B-Complex.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPJ34102.1}.
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DR EMBL; AOPY01001716; EPJ34102.1; -; Genomic_DNA.
DR AlphaFoldDB; S4MKW1; -.
DR PATRIC; fig|1283301.3.peg.8744; -.
DR HOGENOM; CLU_002346_0_0_11; -.
DR Proteomes; UP000015001; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000015001}.
FT DOMAIN 449..704
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 706 AA; 77429 MW; 1C750F40CE3A409E CRC64;
MPDVRTWTAE TPELYGLTVR LHRADGTVAD SSHHRTGFRD VEIIGRDLLV NGERVFIRGV
NRHDFHPLTG RTVSYDDMRA DLVLLKRFGF NAIRTAHYPN DPALYDLADE LGFYVVDEAD
IESHDHAHEI ADDPRYLGAF VDRVARMVLR DKNHPSVIIW SLGNESDYGA NHDAAAGWVR
RHDPTRPVQY EGAAKRGWAD PDLASDIACP MYAPLQECLA HAMSGTQTKP LIQCEYSHAM
GNSNGTLADH WEAIEATPGL QGGFIWEFWD HGILQRVNDG RPAGRGGAGL YDNGVAAPGH
RWAYGGDFGE TDHDGAFIAD GVVFPDRTPK PVMFEHREIA APLRIECFRH EGVVLGNHQH
FRGLDWLSGE WQLALADGGT RTAPAELPDL RPGETAAVPL PFELPEDGGE AWLTLRVTTA
RDEPWAPRGT VVCLPQVRLR HAPPTRHAPV THRAVEVDED GLLVHPLLTA GPTLSLWRAP
TDNDELGGMA ARWRDWGLDA LTRKVVAVRR DPGRVAVVSD HLGPGGTVRH EQVFTAVEGG
LLVEECAELP EALDDVARVG SVFETAAGLN LLEWFGQGPW ESYPDRGAGA PVGHHSLPVD
ELFTPYLRPQ ESGGRHGVRR FTLSAPDATG LAVRLDRPRQ VCVTRHRAAD LASAAHPDEL
VSRAGCVVHI DAAHRGLGTA SCGPDTFASY LVAAGVHRWS WTLRVL
//
