ID   S4MUV8_9ACTN            Unreviewed;      1276 AA.
AC   S4MUV8;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=Peptidase C14 caspase domain-containing protein {ECO:0000259|Pfam:PF00656};
GN   ORFNames=STAFG_2417 {ECO:0000313|EMBL:EPJ40546.1};
OS   Streptomyces afghaniensis 772.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1283301 {ECO:0000313|EMBL:EPJ40546.1, ECO:0000313|Proteomes:UP000015001};
RN   [1] {ECO:0000313|EMBL:EPJ40546.1, ECO:0000313|Proteomes:UP000015001}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=772 {ECO:0000313|EMBL:EPJ40546.1,
RC   ECO:0000313|Proteomes:UP000015001};
RA   Gruening B.A., Praeg A., Erxleben A., Guenther S., Fiedler H.-P.,
RA   Goodfellow M., Mueller M.;
RT   "Draft Genome Sequence of Streptomyces afghaniensis, Which Produces
RT   Compounds of the Julimycin B-Complex.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPJ40546.1}.
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DR   EMBL; AOPY01001369; EPJ40546.1; -; Genomic_DNA.
DR   AlphaFoldDB; S4MUV8; -.
DR   PATRIC; fig|1283301.3.peg.2391; -.
DR   HOGENOM; CLU_263491_0_0_11; -.
DR   Proteomes; UP000015001; Unassembled WGS sequence.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR020575; Hsp90_N.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   PRINTS; PR00775; HEATSHOCK90.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000015001}.
FT   DOMAIN          4..169
FT                   /note="Peptidase C14 caspase"
FT                   /evidence="ECO:0000259|Pfam:PF00656"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1094..1276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1189..1206
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1231..1264
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1276 AA;  140231 MW;  64B795AFE3AFBAC4 CRC64;
     MQALADPTRN EITERVSEVS ASAPPGSTLL LYFTGHGVRI GTTDYLVPAD ARAPADDGDG
     DDAAGWELPH VRESLLEADI SRYLANCRAG TVLWLIDACR AADAGRGGVF GSNVVKGPPH
     SGFAMMTSCG PGELSGGAKT GSFFTAALAR AFDPLTEATT VEQVYEKAKH GTRALAVEAQ
     AGPQQVLIHY GTDLAERTKS LVVAEGRGLL EAWQDAVRTP ALWERVQECD AGTVAHFQDC
     LSALATQAAR HVHHAQRRLP DPWTDDEYPV RLLSDRLPLL LPKGAELSAL EVTALIAGVL
     LHETAWAERL GQAAGFRPRL VWRDDEADDQ RRHYEQITEH YPQITEKLTD SYRWLGDPAD
     DRHAVTLWLV HRWIEERFAT DEEAVPALFA DRFTARLLDV APPAAGERLG GRAEALSQAL
     RTVAAGLALG APPEDERLPP DRHVVRRTPW RLRVRPLAAL LRLAGLLAFD TRCLPEVLAE
     HLAVSDPVLP REVITVFRDA YWVPDRDGSA ASYLHLDAVC PHPALHAALA AVVEDADDLG
     HLLRESARRL PQDEAELLRG LPARLSDHGL RPDRPDGTDA YDVPLARFSL AQTEIRRLLM
     GDKLYDGEPE LALRELYQNA MDACRYREMR VRYLRDLGRD PVPWAGRIRI ETGEDSRGRY
     VECVDNGVGM TVDQLKNTFT RAGRRFDQSH AFRREQAAWL RHDSSLRLYP NSRFGIGVFS
     YFMLADEMTL VTRPVGTDGR PAEKALRVEI PVSGSLFRVR EEDERDGTAL PEGGTRVRLH
     LRRAGALPGG SAVSVLRSLV LISEFLLEVR DQDGTEEIWL PGDLKSGEEP GAFSTRFAVE
     AVPGTLWWVS DKGAIVCDGI ATDQRPFGYV LNLSGAHAGE LSVNRKKLER YDVLWAQEQF
     RQGARAFLGQ ETPGLEWLWS MESRESSIAR VLWEVLRGHG VRASLGHGRR IDLDELGWFR
     LDGGVHGGRG HREGEEASRL VRPWRLAALG SEHRDRHTAP PLSLSGHPVP QPGWADIAEK
     VEGDWRVAVR MADAQNTTVA EVLRATRGLR IAHPQLAGPA VLGDGDLDWE PGITDWYVTT
     GLLGRKRDPL DGFAAPSGEP CGQAAGGRRH SLPAPARGPL RHRPRLRHVP EAARRAGRGV
     RPVRAVRGQA AGHRPGPPPG PRLHRRRAEA PLPPGGQVRL AARRPPLGRA GGGRRHGPRH
     GRGATAHGRL RLAGPPRTRP GSDRTLGRRT GRAARRPAHL PRPPRRRPPR AALGRHHRSG
     RGARSLRVGG RTPPGP
//