ID S4R2J6_MOUSE Unreviewed; 1157 AA.
AC S4R2J6;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Ankyrin 3, epithelial {ECO:0000313|Ensembl:ENSMUSP00000138671.2};
GN Name=Ank3 {ECO:0000313|Ensembl:ENSMUSP00000138671.2,
GN ECO:0000313|MGI:MGI:88026};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000138671.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000138671.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138671.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000138671.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000138671.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR AlphaFoldDB; S4R2J6; -.
DR SMR; S4R2J6; -.
DR jPOST; S4R2J6; -.
DR MaxQB; S4R2J6; -.
DR ProteomicsDB; 349518; -.
DR Antibodypedia; 4197; 352 antibodies from 29 providers.
DR Ensembl; ENSMUST00000183074.8; ENSMUSP00000138671.2; ENSMUSG00000069601.15.
DR AGR; MGI:88026; -.
DR MGI; MGI:88026; Ank3.
DR VEuPathDB; HostDB:ENSMUSG00000069601; -.
DR GeneTree; ENSGT00940000154939; -.
DR ChiTaRS; Ank3; mouse.
DR Proteomes; UP000000589; Chromosome 10.
DR Bgee; ENSMUSG00000069601; Expressed in lateral geniculate body and 255 other cell types or tissues.
DR ExpressionAtlas; S4R2J6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08803; Death_ank3; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR037971; Ank3_Death.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 1: Evidence at protein level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|MaxQB:S4R2J6,
KW ECO:0007829|PeptideAtlas:S4R2J6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 117..272
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 274..421
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 598..682
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1027..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1078
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1157 AA; 128445 MW; 6A0B6B39ED999CB6 CRC64;
MALPHSEDAI TGDTDKYLGP QDLKELGDDS LPAEGYVGFS LGARSASPKI SSDRSYTLNR
SSYARDSMMI EELLVPSKEQ HLTFTREFDS DSLRHYSWAA DTLDNVNLVS SPVHSGFLVS
FMVDARGGSM RGSRHHGMRI IIPPRKCTAP TRITCRLVKR HKLANPPPMV EGEGLASRLV
EMGPAGAQFL GPVIVEIPHF GSMRGKEREL IVLRSENGET WKEHQFDSKN EDLAELLNGM
DEELDSPEEL GTKRICRIIT KDFPQYFAVV SRIKQESNQI GPEGGILSST TVPLVQASFP
EGALTKRIRV GLQAQPVPEE TVKKILGNKA TFSPIVTVEP RRRKFHKPIT MTIPVPPPSG
EGVSNGYKGD ATPNLRLLCS ITGGTSPAQW EDITGTTPLT FIKDCVSFTT NVSARFWLAD
CHQVLETVGL ASQLYRELIC VPYMAKFVVF AKTNDPVESS LRCFCMTDDR VDKTLEQQEN
FEEVARSKDI EVLEGKPIYV DCYGNLAPLT KGGQQLVFNF YSFKENRLPF SIKIRDTSQE
PCGRLSFLKE PKTTKGLPQT AVCNLNITLP AHKKAEKADR RQSFASLALR PQSPCERTDI
RMAIVADHLG LSWTELAREL NFSVDEINQI RVENPNSLIS QSFMLLKKWV TRDGKNATTD
ALTSVLTKIN RIDIVTLLEG PIFDYGNISG TRSFADENNV FHDPVDGHPS FQVELETPMG
LYCTPPNPFQ QDDHFSDISS IESPFRTPSR LSDGLVPSQG NIEHPTGGPP VVTAEDTSLE
DSKMDDSVTV TDPADPLDVD ESQLKDLCQS ECAQCWASVP GIPNDGRQAE PLRPQTRKVG
MSSEQQEKGK SGPDEEVTED KVKSLFEDIQ LEEVEAEEMT EDQGQAMLNR VQRAELAMSS
LAGWQNETPS GSLESPAQAR RLTGGLLDRL DDSSDQARDS ITSYLTGEPG KIEANGNHTA
EVIPEAKAKP YFPESQNDIG KQSIKENLKP KTHGCGRTEE PVSPLTAYQK SLEETSKLVI
EDAPKPCVPV GMKKMTRTTA DGKARLNLQE EEGSTRSEPK DLRNSESDSS SEEEQRITTR
VIRRRVIIKG EEAKNIPGES VTEEQFTDEE GNLITRKITR KVIRRIGPQE RKQDDVQGEG
YKVKTKKEIR NVEKKTH
//
