ID S4R446_HUMAN Unreviewed; 490 AA.
AC S4R446;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Mex-3 RNA binding family member D {ECO:0000313|Ensembl:ENSP00000475059.1};
DE Flags: Fragment;
GN Name=MEX3D {ECO:0000313|Ensembl:ENSP00000475059.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000475059.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000475059.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [3] {ECO:0000313|Ensembl:ENSP00000475059.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AC005943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC027307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; S4R446; -.
DR SMR; S4R446; -.
DR MassIVE; S4R446; -.
DR MaxQB; S4R446; -.
DR PeptideAtlas; S4R446; -.
DR Antibodypedia; 22752; 61 antibodies from 21 providers.
DR Ensembl; ENST00000605173.2; ENSP00000475059.1; ENSG00000181588.17.
DR UCSC; uc060rdj.1; human.
DR HGNC; HGNC:16734; MEX3D.
DR VEuPathDB; HostDB:ENSG00000181588; -.
DR GeneTree; ENSGT00940000162613; -.
DR HOGENOM; CLU_025598_2_0_1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000181588; Expressed in right testis and 120 other cell types or tissues.
DR ExpressionAtlas; S4R446; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22423; KH-I_MEX3_rpt1; 1.
DR CDD; cd22424; KH-I_MEX3_rpt2; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047228; KH-I_MEX3_rpt1.
DR InterPro; IPR047226; KH-I_MEX3_rpt2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047227; MEX3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23285; RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23285:SF3; RNA-BINDING PROTEIN MEX3D; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:S4R446,
KW ECO:0007829|MaxQB:S4R446};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 424..464
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 199..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000475059.1"
SQ SEQUENCE 490 AA; 50314 MW; C57A04FFF9EA5920 CRC64;
VNMTECVPVP SSEHVAEIVG RQGCKIKALR AKTNTYIKTP VRGEEPVFIV TGRKEDVEMA
KREILSAAEH FSIIRATRSK AGGLPGAAQG PPNLPGQTTI QVRVPYRVVG LVVGPKGATI
KRIQQRTHTY IVTPGRDKEP VFAVTGMPEN VDRAREEIEA HITLRTGAFT DAGPDSDFHA
NGTDVCLDLL GAAASLWAKT PNQGRRPPTA TAGLRGDTAL GAPSAPEAFY AGSRGGPSVP
DPGPASPYSG SGNGGFAFGA EGPGAPVGTA APDDCDFGFD FDFLALDLTV PAAATIWAPF
ERAAPLPAFS GCSTVNGAPG PPAAGARRSS GAGTPRHSPT LPEPGGLRLE LPLSRRGAPD
PVGALSWRPP QGPVSFPGGA AFSTATSLPS SPAAAACAPL DSGASENSRK PPSASSAPAL
ARECVVCAEG EVMAALVPCG HNLFCMDCAV RICGKSEPEC PACRTPATQA IRVETETPQP
GGASALQRQY
//
