ID S4R8V3_PETMA Unreviewed; 586 AA.
AC S4R8V3;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Major facilitator superfamily domain containing 6 like {ECO:0000313|Ensembl:ENSPMAP00000001634.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000001634.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000001634.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
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DR AlphaFoldDB; S4R8V3; -.
DR Ensembl; ENSPMAT00000001642.1; ENSPMAP00000001634.1; ENSPMAG00000001481.1.
DR GeneTree; ENSGT00530000063599; -.
DR HOGENOM; CLU_013133_4_0_1; -.
DR OMA; YEYLDFA; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF22; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..528
FT /note="Major facilitator superfamily associated"
FT /evidence="ECO:0000259|Pfam:PF12832"
FT REGION 104..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 60421 MW; 3F7F643BB7380057 CRC64;
VDAQQWDVDR AVVASGLFFL LLGAAGASLL PFLPVYLSVL GLAPLHLGLV ASSRALVHIV
CGPVLLRCAK RSRRRRLTML LALACGATAT LGLTAVPSAQ RKEARLPSDG VTSGFVSPST
VPLNARPAPP DTILPTSATV EARLNHLPTT PTGSAVSPGV DEKPKASWSS TLSSNPSSTT
LLPNAGNHVS STRWGESEEE APPMKLKSSV DDGGKDKEGT TVMVAIKNEK KIPAVTLSAW
RAFALVLAVS TAGAALSSPL HSLADDSLYE YLDQVDATDR YGQHELWSLL GASVAALGAC
ALSQRVDSML PHFYTSSALL AVALLAALAY PVHGAAAPTG PAASLRRALR RTACGPDAGA
LLCAPTLFVL AATGAVVDCF IFCRMRELGG SEMLMGGAVS AAAAGELLLA WLRRGGGALV
RRCQRCPIDL NAGVTAALGI TVFAAQALAY SLLRTPWALA LVYAASGLGA PLAWHAVLRR
VGLECAPGVG ERTARSVAQA LAVGLGAGAG AAAGGALVQE VGVERTFQGC AVLLAIWAAA
FGLVQARAPR PKGLSYSRLL SNESDASDSG DERTRDWLVQ ALEDAD
//
