ID   S4R965_PETMA            Unreviewed;       751 AA.
AC   S4R965;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Hydroxysteroid (17-beta) dehydrogenase 4 {ECO:0000313|Ensembl:ENSPMAP00000001746.1};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000001746.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000001746.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484}.
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DR   AlphaFoldDB; S4R965; -.
DR   STRING; 7757.ENSPMAP00000001746; -.
DR   Ensembl; ENSPMAT00000001755.1; ENSPMAP00000001746.1; ENSPMAG00000001535.1.
DR   GeneTree; ENSGT00940000158343; -.
DR   HOGENOM; CLU_010194_18_4_1; -.
DR   OMA; WATKVHT; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   GO; GO:0048666; P:neuron development; IEA:Ensembl.
DR   CDD; cd03448; HDE_HSD; 1.
DR   CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 1.
DR   Gene3D; 1.10.287.4290; -; 1.
DR   Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR002539; MaoC-like_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR003033; SCP2_sterol-bd_dom.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR   PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   Pfam; PF01575; MaoC_dehydratas; 1.
DR   Pfam; PF02036; SCP2; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SMART; SM00822; PKS_KR; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF55718; SCP-like; 1.
DR   SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT   DOMAIN          496..612
FT                   /note="MaoC-like"
FT                   /evidence="ECO:0000259|Pfam:PF01575"
FT   DOMAIN          645..746
FT                   /note="SCP2"
FT                   /evidence="ECO:0000259|Pfam:PF02036"
SQ   SEQUENCE   751 AA;  81985 MW;  319527FB216DFB47 CRC64;
     IMAQLRFDGR VVLVTGAGGG LGKEYALAFA ERGALVVVND LGGDIKGEGK STSAANKVVQ
     EILTKGGKAV ANHDQTDSVE DGEKLIKSAL DAYGRIDVVV NNAGILRDRT FPRISDQDWD
     IIQRVHLRGS FLVTRAAWNH MKNQKYGRII MTSSSSGIYG NFGQANYSAA KMGLLGLSNT
     IAIEGQKYNV HCNTVAPTAG SRLTQSVMPQ ELVDALKPEF VAPLILWLCH ESCQDTGNIF
     EVGAGWVGKL RWERSNGAIL RTKGKPMTPE AVRDNWGKVC DFTDSTHPKS SQESTIMYLD
     VLRKIDEQQG ISPVPASGTS VGKVSTIFST VLYGQAVGFK MPPFVYEYTW LQPILYSLGV
     GMSTSYDGGR VFLYEGHQDF SCLPTFGVIP AQAILMNGQL SNVPGLSFEP AKSLHGEHYL
     EIFKPLPTSG KMIVEATIAD VLDKGSGCLL LLDALTVYTY NENKEPICFN QFSVFVVGAG
     GFGGKRSSDK VKPTVAIPKR SPDASVTDKT SLDQAALYRL SGDWNPLHID PEFSAVVGFK
     QPILHGLCSF GFSARHVLKQ YANNDTSKFK AIKARFAKPV LPGQTLQTDM WKEGSRVFFQ
     TKVVETGEVV LANAYVDLKG DDTPTVAPQP QEATGLQSEL VFSEIANRIK EKGSDFVKKV
     NAIFQWEITK DGKTAAQWTI DLKTGPGEVY KGNPRKGRAD TTFTLSDEDF LEIVQGKLNP
     QKAFFSGKMK VKGNIMLSQK LEDILKQNAK L
//