ID S4RB06_PETMA Unreviewed; 160 AA.
AC S4RB06;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Glucagon {ECO:0000313|Ensembl:ENSPMAP00000002387.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000002387.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000002387.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glucagon family.
CC {ECO:0000256|ARBA:ARBA00008369}.
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DR AlphaFoldDB; S4RB06; -.
DR Ensembl; ENSPMAT00000002399.1; ENSPMAP00000002387.1; ENSPMAG00000002186.1.
DR GeneTree; ENSGT00390000005372; -.
DR HOGENOM; CLU_090687_1_0_1; -.
DR OMA; ESRNGPM; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR Gene3D; 6.10.250.590; -; 2.
DR InterPro; IPR015550; Glucagon.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR11418; GLUCAGON; 1.
DR PANTHER; PTHR11418:SF0; PRO-GLUCAGON; 1.
DR Pfam; PF00123; Hormone_2; 2.
DR PRINTS; PR00275; GLUCAGON.
DR SMART; SM00070; GLUCA; 3.
DR PROSITE; PS00260; GLUCAGON; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..160
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004522820"
FT DOMAIN 43..65
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT DOMAIN 82..104
FT /note="Glucagon / GIP / secretin / VIP family"
FT /evidence="ECO:0000259|PROSITE:PS00260"
FT REGION 112..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 160 AA; 18027 MW; 855EAE2A6F1CE0D3 CRC64;
MSDAGFLAAP VLLLLLVSLA SASLEQAASR DDDSAERPLS KRHSEGTFTS DYSKYLENKQ
AKDFVRWLMN AKRGGSELQR RHADGTFTND MTSYLDAKAA RDFVSWLARS DKSRRDGGDH
LAENSEDKRH AEDVNALLDR TMAKTFIEWL EKQNSNDQAR
//
