ID S4RB68_PETMA Unreviewed; 372 AA.
AC S4RB68;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=VPS9 domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000002449.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000002449.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIN (Ras interaction/interference) family.
CC {ECO:0000256|ARBA:ARBA00006919}.
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DR AlphaFoldDB; S4RB68; -.
DR STRING; 7757.ENSPMAP00000002449; -.
DR Ensembl; ENSPMAT00000002461.1; ENSPMAP00000002449.1; ENSPMAG00000002247.1.
DR GeneTree; ENSGT00940000154866; -.
DR HOGENOM; CLU_651433_0_0_1; -.
DR OMA; TLNGCGT; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF126; RAS AND RAB INTERACTOR 1-RELATED; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..372
FT /note="VPS9 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004532373"
FT DOMAIN 99..243
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT DOMAIN 279..372
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
SQ SEQUENCE 372 AA; 41557 MW; 6C1C8CF0A63585B9 CRC64;
VSVLDRLSLT CSVWLLLGVD EAAVLHTLQG EKPGTFIVRR SKKTQQKVIS VRWTKGEGCL
FVRNYPILET QSDDVVEKAL YKCVLKPLKP TLEQALMSTH NKQGLVKRLQ SNCFWGRSQL
PTELGVSPSV NTPDSATQER IRAKLSDLAA SYSPMVKVDS LLKVCKMVYN AMGSSGEVRG
ADDFFPVLTY SLLHCDCPQL AIQVDYIMEL LNPNLMSGES GYYLTSVYAA LLMLGSLQEE
QATAELTANT QQSLREFRRS RMTSTAQHST RSQHLPLMVS FRKCGSMTKP FSTRETVTAK
EVCQNCATHF EVTADEAESF GLYAVTIYST GHSEWHFLKD SDCPHSVWAK LTSNNSTSNQ
LVCYFVYKPL DN
//
