ID   S4RC20_PETMA            Unreviewed;       750 AA.
AC   S4RC20;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Amyloid beta (A4) precursor protein-binding, family A, member 1b {ECO:0000313|Ensembl:ENSPMAP00000002752.1};
GN   Name=APBA1 {ECO:0000313|Ensembl:ENSPMAP00000002752.1};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000002752.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000002752.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; S4RC20; -.
DR   STRING; 7757.ENSPMAP00000002752; -.
DR   Ensembl; ENSPMAT00000002765.1; ENSPMAP00000002752.1; ENSPMAG00000002517.1.
DR   GeneTree; ENSGT00940000156820; -.
DR   HOGENOM; CLU_013563_1_0_1; -.
DR   OMA; SENCKDX; -.
DR   Proteomes; UP000245300; Unplaced.
DR   CDD; cd22578; Mint1_CID; 1.
DR   CDD; cd00992; PDZ_signaling; 2.
DR   CDD; cd01208; PTB_X11; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   PANTHER; PTHR12345:SF14; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 1; 1.
DR   PANTHER; PTHR12345; SYNTENIN RELATED; 1.
DR   Pfam; PF00595; PDZ; 2.
DR   Pfam; PF00640; PID; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50106; PDZ; 2.
DR   PROSITE; PS01179; PID; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          370..556
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   DOMAIN          569..654
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          660..736
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   REGION          1..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..61
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..174
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   750 AA;  83459 MW;  B225B5252DE2CCA3 CRC64;
     LARSGSTESG FHNHTDTAED DLSSEYATVR DHDERLPEND DENVYSVEYR PEAEEYLEQA
     ESEHAPMSTA VQPSQHINPR RAEAPVPDQQ VVRQEYQGVE EAYRVFHPRA DHNAEEHVYE
     EIGDHPVADT VYSMEPYEQE REEEDDYDSK QVLGARLHHY DVKSDSESDS PEKDAEYTSY
     PAPDPDSEEE HEEEDIDQIV AEVKQSLSSK SLDRIAQDMP ESEQGWHKEQ GAGAAHSGAE
     CRTSEVSVVS REQREAISLA LKDIQDAIAE VKTKTMRSPY TPEEPAEPIW VMRNDQSPLR
     ELENGIPGEG GGVQNNNGFL LNCSSSSVPI LPGKAHYRES PRQSKWAAKT PQYPSFVDVP
     GPCDPEDLID GIIFAANYLG STQLLSEKNP SKNVRMMQAQ EAVSRIKRAQ KLAKSKKKAP
     EGESQPMTEV DLFISTQRIK VLNADTQETM MDHALRTISY IADIGNIVVL MARRRIPRTA
     SQEGMEASHP GQDSKRQYKM ICHVFESEDA QLIAQSIGQA FSVAYQEFLR ANGINPEDLS
     QKDYSELLNT QEMYNDDLIH FSKSENSKEI IIEKQKGEIL GITIVESGWG SILPTVIIAN
     LMHGGPATRS GKLNIGDQIM SINGTSLVGL PLSTCQTIIK GLKNQTMVKV NIVSCPPVTS
     VLIKRPDLKY QLGFSVQNGI ICSLMRGGIA ERGGVRVGHR IIEINGQSVV ATPHEKIVHA
     LSNAVGEIHM KTMPAAMYRL LTGQEQPVYF
//