ID S4RCL5_PETMA Unreviewed; 462 AA.
AC S4RCL5;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Potassium channel subfamily K member c {ECO:0000313|EMBL:QBP05218.1};
DE SubName: Full=Potassium channel, subfamily K, member 13a {ECO:0000313|Ensembl:ENSPMAP00000002947.1};
GN Name=KCNK13 {ECO:0000313|Ensembl:ENSPMAP00000002947.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000002947.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|EMBL:QBP05218.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30878501;
RA Northcutt A.J., Hough R.A., Frese A.N., McClellan A.D., Schulz D.J.;
RT "Genomic discovery of ion channel genes in the central nervous system of
RT the lamprey Petromyzon marinus.";
RL Mar. Genomics 0:0-0(2019).
RN [2] {ECO:0000313|Ensembl:ENSPMAP00000002947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR EMBL; MH726122; QBP05218.1; -; mRNA.
DR STRING; 7757.ENSPMAP00000002947; -.
DR Ensembl; ENSPMAT00000002961.1; ENSPMAP00000002947.1; ENSPMAG00000002706.1.
DR GeneTree; ENSGT00940000157960; -.
DR HOGENOM; CLU_022504_3_1_1; -.
DR OMA; FSTVLFC; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR005410; 2pore_dom_K_chnl_THIK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR PANTHER; PTHR11003:SF10; TWIK FAMILY OF POTASSIUM CHANNELS; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01588; THIKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000256|RuleBase:RU003857, ECO:0000313|EMBL:QBP05218.1};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 40..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..169
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 224..302
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 50335 MW; 646E97A2A0370D6A CRC64;
LTEKSPRSAP RPATQNSAPR PATQTTMARV SLGGEDTARF ALLAALILCY LLCGAAVFSA
LERPSELVAQ ERWLHRLENF TQHFGVPRAD LDALLRDFEL GATAGVRAAP LRPRWDFTGA
FYFVGTVVST IGFGMTTPTT VSGKIFLIFY GLFGCAAGIL FFNLFLERLI TLLACVMRSC
HRRQINRLVI QPGRKASDQS DAIECLAGWK PSVYHVMMIL GIAAVAIACS ASAMFSAVEG
WSYVDSLYFC FVAFSTIGFG DLVTGQRDLY DHQTWYRVGN IVFILAGVCC IYSLFNVLSI
VIKQTLTWML HKADCRSLCR RRPRLRARNQ RRNAVMPGVP RGRRNNNNND AAGGGGGGGG
VETVAAPGPR RYDGGAGNDS DTDGRRLSGE LISMKDFLAS NKVSLALMQK QLSEAANGHH
HRVAHRCSPV HSHSLGRENG FAAGVGALAI MNNRLAETSE DR
//
