ID S4RCW9_PETMA Unreviewed; 689 AA.
AC S4RCW9;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=WD repeat-containing protein 91 {ECO:0000256|ARBA:ARBA00021116};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000003051.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000003051.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004414}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR91 family.
CC {ECO:0000256|ARBA:ARBA00006128}.
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DR AlphaFoldDB; S4RCW9; -.
DR STRING; 7757.ENSPMAP00000003051; -.
DR Ensembl; ENSPMAT00000003066.1; ENSPMAP00000003051.1; ENSPMAG00000002798.1.
DR GeneTree; ENSGT00390000001566; -.
DR HOGENOM; CLU_022078_0_0_1; -.
DR OMA; KMYLVNA; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0141039; F:phosphatidylinositol 3-kinase inhibitor activity; IEA:InterPro.
DR GO; GO:0045022; P:early endosome to late endosome transport; IEA:InterPro.
DR GO; GO:0051898; P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR039724; WDR91.
DR PANTHER; PTHR13083; UNCHARACTERIZED; 1.
DR PANTHER; PTHR13083:SF3; WD REPEAT-CONTAINING PROTEIN 91; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 353..385
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 496..558
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 503..544
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 224..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 74983 MW; B1F81EC53C4B65C9 CRC64;
MSGAVERLDV LVRDFLVFRG FAATLRAYEA ELRGDRDSGA RVDTISLPPS QLCVSSLDLQ
SLRDLWAHLE KRLFSRLEHA HLLTTCKLRT GVLRAYVAHS VQAGRPDKTL EFFQRVGPEL
HGSSEWREWF ALPFLPSPET HSTFSAYFTK QWSDTLWLSL HNFLSVLLHT MPVPSLLCFD
SEVQRSNILQ EENEALRFKL YGQVEAQKPR KLADVPSVRA GEADVAVTAE QKSRQASGST
QKSSSVKKQT TPLRKDAAVC ESGRSGGARD GRQTERARRN GQSERESRQQ LLKPSALGVE
KRPDSEQSAT DSPGKAEAQS KASATAVAAS GAARINREEA SQQPFLVLCQ EEYSEHHSPI
MHCKFDASGS RVASVDVDGV VKVWSCSPTP QTHTTVMAKS PLLSLEWATK PHRLLLLGSG
IGSVRFYDTD QKKSVADVTL DMAYPRVLAL ACSPTGGSFV CGAAASAHGN GTSPPEAAGG
SATRGQLSLW DAKTLRQQHL FTLDPEPVAI TCVSFNHNGN LLVCGATDGL IRLYDVQRYD
CLMSWRAHHG EVCSVEFSGD ETGVFSMGAD GKFTQWHLQR EGARVAELEV HADAAGPFEV
CGCSGYKQTH APRGRLFAFE PSSGQHVLTC SAHGGIVYRL ESGSLSPCLT LGGHRAPVVT
VEWTTAMDCG MCLTASMDGK IRVSTLLAQ
//
