ID   S4REN6_PETMA            Unreviewed;       324 AA.
AC   S4REN6;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000003668.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000003668.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; S4REN6; -.
DR   STRING; 7757.ENSPMAP00000003668; -.
DR   Ensembl; ENSPMAT00000003684.1; ENSPMAP00000003668.1; ENSPMAG00000003362.1.
DR   HOGENOM; CLU_859289_0_0_1; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR045046; Vps9-like.
DR   PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT   DOMAIN          1..124
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          220..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   324 AA;  34407 MW;  97A94FA23BF53694 CRC64;
     RQERLFGPRG TDEFRARVLE AVEVNVTRLV ALVNRFASSL RRSTHCFPTV LRWVASQAYV
     TLARAEGLSP GEARAVCTDL LLACFICPAL VNPEQYGVIT DAPINEVARF NLMQVGQALQ
     QLAMLGCEES DSRMKNIVSR FDRSCVSSFV DVIIGARVLE SPPLSSYNLM EGLSRTTVFI
     TAEQLQGMIG FLHAVLAANS LADDDRSWLE SLLARLPSQP PLGAGGGTTS SGSSHALCSQ
     GCTPSATPHV SPATTPSSKK NLLQIAAGRS LGRLSVAGGQ QPQDCDGDAA SGDGYPEEVP
     EEVLVLSLGA SCSDVLPGLM SENE
//