ID S4RF57_PETMA Unreviewed; 1099 AA.
AC S4RF57;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2 {ECO:0000313|Ensembl:ENSPMAP00000003839.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000003839.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000003839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; S4RF57; -.
DR STRING; 7757.ENSPMAP00000003839; -.
DR Ensembl; ENSPMAT00000003855.1; ENSPMAP00000003839.1; ENSPMAG00000003473.1.
DR GeneTree; ENSGT00940000156303; -.
DR HOGENOM; CLU_004111_2_1_1; -.
DR OMA; NCTEDNI; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1043..1065
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 46..227
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 350..410
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 412..469
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 473..534
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1099 AA; 121105 MW; 8F1C9DB75CD6F5A5 CRC64;
SCAPLWAHEC GSLYFPVGAC AVAGPNFQQL GSPFAPTMTG CRSFLDIVLV LDGSNSIWPW
PSVLDFLSSI LETFSIGPGQ TQVGIMQYGE TVSNEMNLNQ FTNKAQLKIA ASKIPQRGGK
VTNTAMGIEA ARFFFFENGG RAEASKVMIV VTDGESSDAY KLPGVIKDCN DDGITRFGIA
VLDYYISSNM NVEKLQAEIR SIASTPTEKY YFDVKSTGAL VDITKALGER IYSLEGTSDI
STFEMELSEA GFSILPVKDG WLLGAVGAFD WLGTVLHVPD AGGAGSVLLP RAALAAEFPP
SLKNHNNYLG YSLSSASLQG KTLYIAGAPR YNHTGKVVTF GMDDTSRDYA IRQSLVGQQI
GSYFGGEVCA MDVDGDSVSD VLLVAAPMFM DSSSRETGRV YLYTFSPQLE WSAHLSPAES
QDSRFGSALA AVPDLNQDGW GELAVGAPLE DERQGAVYLF QGHGRSLRTT HVQRVAASTL
GLHRLQYFGR ALHGMLDMDR SGIPDLAVGA NGKAVLLWSR AIARVSVTVK FNPNKINMMD
KTCKGLGQDA VCVMAQMCLS ANVRPAQMAS SLLELVYNMT LDPVRSVSRA HFVGGVERTL
QGTATVRPDT SSPFCRDYTF YVMELADIVK PLELRVDLAL KDPEQGPVLD VEELSSKIFE
LPFTKDCGTD ERCETDLVLT LEHDIKGTRM MQYVMNYKRR PQARVCLSIQ TIFAESPYVV
RSERKKHVVS ITLENRRENA YNTRLNFTYS PNQELRNIDT EDGDVSVDCT VHKDHPHSQL
CKIGFPVFRA SAKMTIRFIF EFSRKNIMST ASFSAEVKSD SEETAQQLEN NSARISVPLY
YEADIILFRD SNLAQLEVND KTQRLDIIKG LDDIGPELKY TFKVQKFGFP LPEEIKLKIS
LPMFTAQKNR LLYVTNVHSS PPEMMKCDTT GIVDPLNIAK HQYEVQQTTE DLSNVEKLTC
PDVQCSVFTC TLGRLDEGKD ASVTITSRFW NTTFATAKFK SVKLVSRGRL ELGPSSFLLI
PKGSEERTVE LEVTRLENGE VPVGIIIGSI IGGLLLLALL IFGLWKLGFF QRRYKQLLQD
AGPEGGETNP LSDMNTIEE
//
