ID S4RGQ4_PETMA Unreviewed; 523 AA.
AC S4RGQ4;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Poly(A)-specific ribonuclease PARN {ECO:0000256|ARBA:ARBA00015918};
DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
DE AltName: Full=Polyadenylate-specific ribonuclease {ECO:0000256|ARBA:ARBA00031923};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000004386.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000004386.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001663};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR AlphaFoldDB; S4RGQ4; -.
DR STRING; 7757.ENSPMAP00000004386; -.
DR Ensembl; ENSPMAT00000004403.1; ENSPMAP00000004386.1; ENSPMAG00000003956.1.
DR GeneTree; ENSGT00940000153167; -.
DR HOGENOM; CLU_018030_1_1_1; -.
DR OMA; LTTCHED; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR CDD; cd02637; R3H_PARN; 1.
DR CDD; cd12428; RRM_PARN; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034042; PARN_R3H.
DR InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF44; POLY(A)-SPECIFIC RIBONUCLEASE PARN; 1.
DR Pfam; PF04857; CAF1; 1.
DR Pfam; PF08675; RNA_bind; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS51061; R3H; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 176..243
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
SQ SEQUENCE 523 AA; 59200 MW; 414CA51624F5ED48 CRC64;
MEVTRKNFRA TLSVVREAIN EADFLALDGE FTGISDGPLS NGLDTPSDRF NKLRKHSLDF
LLFQFGLCTF RYDSTLEKYI IKAFNFYVFP RPLFRNSPDV KFVCQSSSID FLAAQGFDFN
KVFQEGIPYL SQEGEKKVRE IVEERTRQSG AGSTGVTLFA SPASSKGLAV VPDDQKEYIA
DVVSKVENLL NDPKQTTLDL PPCNAFQRKL VYQTMNSKFP TGLHFETLQN EKRDRYIVVT
KVSEEERRKK EEDKHSKGLE ELEDAVGFTR VIQAISKSGK LLVGHNMLLD VMHTVHQFYS
PLPESLDEFK ELTNCVFPRL LDTKLMSSTH PFKEVIQFTT LADLHRRLSE APFKMPAVAS
AEGFPAYSTA VEQLHEAGYD AYITGLCFAS MANYLGSFMD PPKSHIPARS HLIEPFVNKL
FLMRIIDIPY LNLTGPDLKP NRDHVLHVTF PKEWRTSDLH QLFSAFGNIQ VSWIDDTSAF
VALSKTEQVQ IAKNTSSEAE SYRIQTYSEY LQQGQDGLLK SAG
//
