ID S4RGV2_PETMA Unreviewed; 486 AA.
AC S4RGV2;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 {ECO:0000256|ARBA:ARBA00020285};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000004434.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000004434.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC Evidence={ECO:0000256|ARBA:ARBA00001432};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the SAMHD1 family.
CC {ECO:0000256|ARBA:ARBA00005776}.
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DR AlphaFoldDB; S4RGV2; -.
DR STRING; 7757.ENSPMAP00000004434; -.
DR Ensembl; ENSPMAT00000004451.1; ENSPMAP00000004434.1; ENSPMAG00000004039.1.
DR GeneTree; ENSGT00390000013867; -.
DR HOGENOM; CLU_026821_1_2_1; -.
DR OMA; DYIARDC; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.70.2760; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Allosteric enzyme {ECO:0000256|ARBA:ARBA00022533};
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 1..53
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 107..259
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 486 AA; 55898 MW; 996D895D8652E260 CRC64;
GFKEYILLLF FTEHNITGTV LPDITEDHLK TIGVKKLGNQ LKVFQVLKIM CQDSKQNMKV
FNDPIHGHIV MHPLLVRIID TPQFQRLRNI KQLGGTYWVF PGASHNRFEH SMGVGYLAGQ
LATAIQSRQP ELGINERDVL CVQIAGLCHD LGHGPFSHMF DNSFIPAARP GCKWKHEVAS
VQMFDHLVQA NGLEEVLSKE YGLKLPEDLD FIKEQIAGPL ADIADSKWPY KGRTKDKGFL
YEIVANKSNG IDVDKWDYFA RDCHHLGIQN NFDHRRFIEF VRVCEVENER TKKVICFRNK
EVGNLYDMFH TRNCLHRRAY QHRVGNIIEL MIKEAFLKAD KYIKIEGSGG KMFSISGAID
DMVAYTKLTD LIFYEILHSR DPNLKEARVI LENVVCRRLY KFVNHTQPGE ATLPKEPDEV
KLAKEIANSE PEMPLNVKLN PEDFVVHVIN LDYGMKEKNP INNVWFYCKE DPDKPFRICR
TQASAS
//
