ID S4RJ43_PETMA Unreviewed; 255 AA.
AC S4RJ43;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=nitric-oxide synthase (NADPH) {ECO:0000256|ARBA:ARBA00012989};
DE EC=1.14.13.39 {ECO:0000256|ARBA:ARBA00012989};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000005225.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000005225.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SIMILARITY: Belongs to the NOS family. {ECO:0000256|ARBA:ARBA00006267}.
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DR AlphaFoldDB; S4RJ43; -.
DR STRING; 7757.ENSPMAP00000005225; -.
DR Ensembl; ENSPMAT00000005244.1; ENSPMAP00000005225.1; ENSPMAG00000004768.1.
DR GeneTree; ENSGT00940000168337; -.
DR HOGENOM; CLU_094991_0_0_1; -.
DR OMA; NGEFRIW; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004517; F:nitric-oxide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro.
DR InterPro; IPR044943; NOS_dom_1.
DR InterPro; IPR004030; NOS_N.
DR InterPro; IPR036119; NOS_N_sf.
DR PANTHER; PTHR43410; NITRIC OXIDE SYNTHASE OXYGENASE; 1.
DR PANTHER; PTHR43410:SF1; NITRIC OXIDE SYNTHASE OXYGENASE; 1.
DR Pfam; PF02898; NO_synthase; 1.
DR SUPFAM; SSF56512; Nitric oxide (NO) synthase oxygenase domain; 1.
DR PROSITE; PS60001; NOS; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022643};
KW FMN {ECO:0000256|ARBA:ARBA00022643}; Heme {ECO:0000256|ARBA:ARBA00022617};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 116..123
FT /note="Nitric oxide synthase (NOS)"
FT /evidence="ECO:0000259|PROSITE:PS60001"
SQ SEQUENCE 255 AA; 29349 MW; 8071420117F597CC CRC64;
RFTKIRNIET GHEFRDTLHL QSNKSGMCPG ICKGSIMSPE ELMCPSRDSP KPRPELLEAA
QKFITQYYAS RKGLESAEYV ERLMEVAQEV EKRGTYDLTR DELIYGAKTA WRNAARCIGR
IQWSKLQLFD ARNCTTPSEM FTCICDHVKF ASNGGNIRST ITVFRQRIYG QHDFRVWNSQ
LISYAGYRQP DGSVLGDPAY VEFTELCVEL GWQPPRTRFD VLPIVLQGNG EPELFVLPPE
LVLEVPIRHP NKYHW
//
