ID S4RKD0_PETMA Unreviewed; 1159 AA.
AC S4RKD0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Dynein axonemal heavy chain 9 {ECO:0008006|Google:ProtNLM};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000005663.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000005663.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR AlphaFoldDB; S4RKD0; -.
DR STRING; 7757.ENSPMAP00000005663; -.
DR Ensembl; ENSPMAT00000005687.1; ENSPMAP00000005663.1; ENSPMAG00000005143.1.
DR GeneTree; ENSGT00940000154076; -.
DR OMA; ERYFNFA; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF4; DYNEIN AXONEMAL HEAVY CHAIN 17; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 36..365
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 524..642
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 859..957
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 1003..1159
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
SQ SEQUENCE 1159 AA; 131558 MW; 207106BD5729462B CRC64;
QVENSQAFVW LSQLRHRWDD ERKHCFANIC DAQFLYSYEY LGNTPRLVIT PLTDRQRCYI
TLTQSLHLTM SGAPAGPAGT GKTETTKDLG RALGIMVYVF NCSEQMDYKS CGSIYKGLAQ
TGAWGCFDEF NRISVEVLSV VAVQQVKCIQ DAIRDKKKRF NFQGEEINLV PSVGIFITMN
PGYAGRTELP ENLKALFRPC AMVVPDFELI CEIMLVAEGF IEARLLARKF ITLYQLCKEL
LSKQDHYDWG LRAIKSVLVV AGSLKRSDPD RPEDQVLMRA LRDFNVPKIV TDDLPVFMGL
IGDLFPALDV PRKRDPEFER AVKESVLDLK LQAEDNFVLK VVQLEELLAV RHSVFVVGGA
GTGKSQVLRS LYRTYQLARR RPVWADLNPK AVTNDELFGI INPATREWKD AGLFSTIMRD
LANISHDGPK WIVLDGDIDP MWIESLNTVM DDNKVLTLAS NERIPLNPTM RLLFEISHLR
TATPATVSRA AGILYINQAD LGWNPPVSSW VDGREVQSER ANLSILFDKY LPMCLDTLRT
RFKKIIPIPE QSMVQMLCHL LECLLTPTNA PPDSPKELYE LYFVFAAVWA FGGAMFQDQL
VDYRTEFSKW WVTEFKTIKF PSQGTVFDYY IDPESKKFEQ WTKLIPKFEL DPEIPLQACM
VHTMETMRVR FLMDLLMERR RPVMLVGGAG TGKSVLVGDK LSALDGDAYA VKNVPFNYYT
TSAMLQAVLE KPLEKKAGRN YGPPGTRRLV YFVDDMNMPE VDAYGTVQPH TLIRQHLDYN
HCLFHPSRRE IKSNRRVKKT QSRDRHFFTI NSRLQRHFCV FALSFPGSEA LSSIYSSILG
QHLRGSSFPA ALQKTVPALV GLALALHQKV SSAFLPTAVK FHYIFNLRDL SNIFQGILFS
TPECIKVPQD LMKLYLHESN RVYRDKMLEE KDFQNFDKIQ VDTVKRFYDD IDETLAQAQQ
MNVFCHFASG VGEPKYLPAA SWEYLNRILV EALDNYNETN AVMSLVLFED AMAHSCRINR
ILESPRGNAL LVGVGGSGKQ SLTRLAAFIS SIEVFQITLK KGYGIPDLKA DLANLYIKAG
VKNLSTLLLM TDAQVADEKF LVLVNDLLAS GEIPDLFPDD EVENVIGSVR NEVKAAGLLD
TRETCWRFFI DRVRRNLKV
//
