ID S4RLP8_PETMA Unreviewed; 642 AA.
AC S4RLP8;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Ankyrin repeat and SOCS box containing 2a, tandem duplicate 1 {ECO:0000313|Ensembl:ENSPMAP00000006134.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000006134.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000006134.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; S4RLP8; -.
DR STRING; 7757.ENSPMAP00000006134; -.
DR Ensembl; ENSPMAT00000006163.1; ENSPMAP00000006134.1; ENSPMAG00000005558.1.
DR GeneTree; ENSGT00940000155490; -.
DR HOGENOM; CLU_023739_2_0_1; -.
DR OMA; WTCIKEK; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03587; SOCS; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR InterPro; IPR003903; UIM_dom.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF165; IPT_TIG DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 7.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS50225; SOCS; 1.
DR PROSITE; PS50330; UIM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 176..208
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 209..241
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 242..274
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 308..340
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 374..398
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 417..446
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 447..476
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 600..642
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 37..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 642 AA; 70988 MW; D76EC220F4CAC2CE CRC64;
HAHTSQNMAS GHSLDAEDYS LYSSLGEEEL IRMAVEQSLQ EPRPQRPRAS AGRRGARAAG
EFQTLEFRPQ FTRSRGKKKS TSPCLLTSGL FLFVPNMYFS LRWKVASQRL LDPVWEAVSA
DDGTALTRLR RSGAELRAAT PHGWMAVHEA AYHDKPCCLG ILLQAHPDTV DARSKQNETP
LYLAAYRGHV ACVRILLAEN ATVDACRHVK ETPLYKACEI NNSEVASLLI ARRADVNYRN
IYGNMPLHEA TSKGNLELVK LLVAYGAKLQ FKNKFGICPF FMAAQCVSLE TASPLIEQCV
DVNSEACDGT TVLFEAAKNG HADVVEFLLS QGADPNRPTK DGLLPIHVVA ANGNEGIVEQ
LLMPVTDERQ VRRSGISPLH LASKNGHSDV LELLLSSGGL DVNATLSMDR SRLYEDCRST
PLYFAIINGD YRCAELLLEA GANPNIDLLN PLLVASRMHA YPLVRLLLNH GANVNAYIPA
RPTAFPATIM VCLRDLRILK LVLERGADGG ACFECPFGSG EHPPLPEKLK PWEERLALTS
EASYVQFCEM VASPEINSWA GPIIDTILHF VANVRLCSRL KEQLDTFQEW TLVKDIAGCP
RPLAHLCRLQ IRASVGSQRV VLLEKLPLPR PLLNYLRYKD DD
//
