ID   S4RLQ4_PETMA            Unreviewed;       877 AA.
AC   S4RLQ4;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Tuftelin-interacting protein 11 {ECO:0000256|ARBA:ARBA00015137, ECO:0000256|PIRNR:PIRNR017706};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000006140.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000006140.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Involved in pre-mRNA splicing, specifically in spliceosome
CC       disassembly during late-stage splicing events.
CC       {ECO:0000256|PIRNR:PIRNR017706}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR017706}.
CC   -!- SIMILARITY: Belongs to the TFP11/STIP family.
CC       {ECO:0000256|ARBA:ARBA00010900, ECO:0000256|PIRNR:PIRNR017706}.
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DR   AlphaFoldDB; S4RLQ4; -.
DR   STRING; 7757.ENSPMAP00000006140; -.
DR   Ensembl; ENSPMAT00000006169.1; ENSPMAP00000006140.1; ENSPMAG00000005546.1.
DR   GeneTree; ENSGT00390000012739; -.
DR   HOGENOM; CLU_007977_1_1_1; -.
DR   OMA; QNEFNPH; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000390; P:spliceosomal complex disassembly; IEA:InterPro.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR022783; GCFC_dom.
DR   InterPro; IPR022159; STIP/TFIP11_N.
DR   InterPro; IPR024933; TFP11.
DR   InterPro; IPR045211; TFP11/STIP/Ntr1.
DR   PANTHER; PTHR23329:SF1; TUFTELIN-INTERACTING PROTEIN 11; 1.
DR   PANTHER; PTHR23329; TUFTELIN-INTERACTING PROTEIN 11-RELATED; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   Pfam; PF07842; GCFC; 1.
DR   Pfam; PF12457; TIP_N; 1.
DR   PIRSF; PIRSF017706; TFIP11; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW   ECO:0000256|PIRNR:PIRNR017706};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW   ECO:0000256|PIRNR:PIRNR017706};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR017706};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW   Spliceosome {ECO:0000256|ARBA:ARBA00022728, ECO:0000256|PIRNR:PIRNR017706}.
FT   DOMAIN          160..206
FT                   /note="G-patch"
FT                   /evidence="ECO:0000259|PROSITE:PS50174"
FT   REGION          26..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          297..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          774..799
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          354..388
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        26..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..234
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        779..798
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   877 AA;  98253 MW;  DF021A053AF6EC29 CRC64;
     MSMSHLYGRD EDVNVERFEV TDWDLENEFN PERVRHRQSK EEAVYGVWAE DDDDDDERPG
     FSGGRSKNRD FTAPVSFVSG GVKRPAAEEE EDEDEDEEGV SGKGSGGEED GARLGPWTEA
     LQRAKGGRGA RQSQKGGIRP SRTVAGLPPE KGFGSWERHT KGIGQKLLQK MGYVPGLGLG
     KNAQGIVLPV EAKVRKGRGA IGAHGPERTK QSLHDFPAPK SDEEEEEEFK QQLSQWRKEP
     GTGAGATKKG PRYTYRTVEE LKAKGLGRKV APPSQLSQVK VIDLTGKSQK VYYSYDQMSQ
     RHSVPSDEAE AAEGETAAPS ESKRKGFALP ELEHNLQLLV ELTEQDIVQT DRRLRHEKNQ
     VVALQHEAQR LEALLEQEDR AVERLGRVLA VAESCERRAR SLEGDVPPGE GEPPLGLADA
     ARVFRSLQSE FYEEYRAFDL ATLAVLTVQP LLKQSFAGWD PLKDPSFGLD VAREWKAILE
     ESQNVLQTVH PQLGPLAGSS GGGGGTNMDP YHRLMWDTWM PCVRSAVVRW QPRACEPMVD
     MVEHWMEFLP PWILNNVLEQ LIFPKLQREV ENWNPLTDTV PIHAWHPWLP LMGGARLEPL
     YSPIRSKLGS ALQRWHPSDP SAKLILRPWK EVFSPGSWEA FMLKHILPKL GMCLSDFVIN
     PHQQHLDPFR WVIDWEGMLS PASLVTLLDK HFFAKWLQVL CAWLSNNPNY EEIIKWYQGW
     KSLFSEQLLA HVTVKEKFSE ALDIMNRAVS RPVGFTQPGA REHIAYLTQT ERRRDFQPDG
     GPAPPPASAV PPGPPGPAGG LAVGVAQPVP LSFKELVQAR AEENNIVFMP LLGRRHEGKQ
     LYTFGRQVAY IDRGVVFVQG EKTWVPTSLQ SLVDSAK
//