ID S4RMA9_PETMA Unreviewed; 605 AA.
AC S4RMA9;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=PR domain containing 8b {ECO:0000313|Ensembl:ENSPMAP00000006345.1};
GN Name=PRDM8 {ECO:0000313|Ensembl:ENSPMAP00000006345.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000006345.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000006345.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; S4RMA9; -.
DR STRING; 7757.ENSPMAP00000006345; -.
DR Ensembl; ENSPMAT00000006374.1; ENSPMAP00000006345.1; ENSPMAG00000005756.1.
DR GeneTree; ENSGT00890000139463; -.
DR HOGENOM; CLU_034617_1_0_1; -.
DR OMA; FVYTTAF; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16516; AGAP007109-PA; 1.
DR PANTHER; PTHR16516:SF4; AGAP007109-PA; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF13894; zf-C2H2_4; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 17..132
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 541..569
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 582..605
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 264..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 65041 MW; 343E5D061F8C90C5 CRC64;
VEAAGMVVKG QWDDDVRAVQ QRLTDIFTSV FTTCDVPEHA ILGPCLLSSA SFIDTIAFIA
LKAADKRTAP YIFRVDSTAS QGAADGVAWL RLVQPARDRA EQNLEAYLKN GQLFYRSLRK
ISRDEELLVW YGRELAALLR LDDTVPHKAA NGGSPSSPLL RCGECQQAFH FEFPYAAHLR
FLCQKRRDFS ILHENLRILA FPGGGPAQHH HHHGGGGAAV LSPAALLHQH LLEGKRAAAA
ATAAAAGLLL ESGKRVTNFH SLAHDMEKAR RPSSDADERP PAKRARVSAK LLPASGDSPL
AGASKGDSAL VTKPASAPVV GALDEHRDAA ATTTTGGGSD GGSRDERVVK DGRERSSDDL
DEVREAPRRP CYATDVLQHG SKRSAFTEVV RKAGKERAED EACEAFAAAL RSRSASAELC
GGAKALSETR AEVAINAAAA FTSLLKSPLG GAERKSAFSQ PVRPFAQLSA SMLPPSMQGS
KQHGLEINGG GGGGAGGLQN ATPFLLAPAF WPKATAIPVQ LPGALPLLPP TLTPLGLPAQ
NWCAKCNTSF RMTSDLVYHM RSHHKKEYAE EPVLKRRRED KLKCPICNET FRERHHLSRH
MTSHN
//
