ID S4RMW5_PETMA Unreviewed; 864 AA.
AC S4RMW5;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Pre-mRNA-splicing factor CWC22 homolog {ECO:0000256|ARBA:ARBA00040488};
DE AltName: Full=Nucampholin homolog {ECO:0000256|ARBA:ARBA00042174};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000006551.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000006551.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the CWC22 family.
CC {ECO:0000256|ARBA:ARBA00006856}.
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DR AlphaFoldDB; S4RMW5; -.
DR Ensembl; ENSPMAT00000006580.1; ENSPMAP00000006551.1; ENSPMAG00000005914.1.
DR GeneTree; ENSGT00940000153458; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR18034; CELL CYCLE CONTROL PROTEIN CWF22-RELATED; 1.
DR PANTHER; PTHR18034:SF3; PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51366; MI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 418..540
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..428
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..660
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..864
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 99943 MW; 38C06877D0FAA5BC CRC64;
KREGGRNRKG DRDHGRERSS DKDEGFRNKD RDRDRHRDLD EDEGRYRDRD RNRNMIEDEG
RYRDGGRDRY RDRGRDRDVE RRKRGKSPTQ DEAERDGEVT GGEEPPTKKK KDEVDPILTR
SGGAYIPPAR LRMMQEQIAD KSSLAYQRMS WEALKKSING LINKVNVSNI FNIIKELLQE
NIVRGRGMLS RSMIQAQMAS PTFTHVYSAL TAIINSKFPQ IGELILRRLI LNFRKGYRRN
DKPLCLSTSK YIAHLVNQNV AHEVLSLEIL TLLLERPTDD SVEVAVGFLK ECGLKLTEVS
PRGINAIFER LRNILHESQI DKRVQYMIEV MFAIRKDGFK DHPVIPEGLD LVEEDDQFTH
MLPLEDDYNS EDLLNIFKLD PDFLNNEEKY KAIKKEILDE GSSGEGESGE GEGSDSDDEE
EDEEEAVEEK GGDKSVLDFE ECAHKLLKME LPAGQEKELC NMILDCCAQQ RTYEKFFGLL
AGRFSLLKKE YMESYEALFR EQYEAIHRLE TNKLRNVAKL FAHLLFTDSI PWSVLESVVL
SEDTTTSSSR IFVKILFQEL CEYMGLPRLN TRLKDETLQP FFEGLFPRDN PRNTRFAINF
FTSIGLGGLT DELRDHLKIA PKLIMAQRQE VESDTSSSSS SSSSDETDDT DDDSDSSSDD
DVDSSSGSGS SGSSESTGSA DSSSEEKQGK AQKKDASQTK RTSRRGREGD EETSQRGDRR
QREAQRSETN RERGERGGDA EKPFRDRSQD RHRDRAPVGI RGGSQDRHQD RFQDRRRDNS
EERHIDGSQE KQNTFPDRHQ ERSSDRRKDK SADRRREKSP ERRKERTPDR HREKSPERHK
EKSSERRRER SPERRKEKSP ERHR
//
