ID S4RNB8_PETMA Unreviewed; 556 AA.
AC S4RNB8;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Lipoxygenase domain-containing protein {ECO:0000259|PROSITE:PS51393};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000006704.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000006704.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|PIRSR:PIRSR601885-1};
CC Note=Binds 1 Fe cation per subunit. {ECO:0000256|PIRSR:PIRSR601885-1};
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DR AlphaFoldDB; S4RNB8; -.
DR STRING; 7757.ENSPMAP00000006704; -.
DR Ensembl; ENSPMAT00000006734.1; ENSPMAP00000006704.1; ENSPMAG00000006039.1.
DR GeneTree; ENSGT00940000156111; -.
DR HOGENOM; CLU_004282_3_3_1; -.
DR OMA; MEGTKEF; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR GO; GO:0034440; P:lipid oxidation; IEA:InterPro.
DR Gene3D; 3.10.450.60; -; 1.
DR InterPro; IPR000907; LipOase.
DR InterPro; IPR013819; LipOase_C.
DR InterPro; IPR036226; LipOase_C_sf.
DR InterPro; IPR001885; LipOase_mml.
DR PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR PANTHER; PTHR11771:SF153; LIPOXYGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00305; Lipoxygenase; 2.
DR PRINTS; PR00087; LIPOXYGENASE.
DR PRINTS; PR00467; MAMLPOXGNASE.
DR SUPFAM; SSF48484; Lipoxigenase; 1.
DR PROSITE; PS51393; LIPOXYGENASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|PIRSR:PIRSR601885-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601885-1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 9..556
FT /note="Lipoxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51393"
FT BINDING 259
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
FT BINDING 264
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
FT BINDING 434
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
FT BINDING 556
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR601885-1"
SQ SEQUENCE 556 AA; 63094 MW; 87A62588887D1F04 CRC64;
MELREGLGIL PQHETLAQLK EKRAEELSAR RHSLRWLEWQ AGLPLGVDSK SFLDLPCDTR
FDDEKSADFN LSFLQSVQDL GLRVFMNLDG MSWTKIEDFR RLFTRVKSEI AEYISHHWDQ
DWFFGYQFMN GVNPVLIKRC TKLPENFPVT TNMVKSSLVR ECSLEDEIKH GNVYIVDYQC
LDGIPGNTFN HSKPFYLAAP MCLLYVNKQG QLLPIAIQLQ QKPSADNPIF LPSDSAHDWM
LAKMWVRSMD FQIHEISTHL LKTHLLAEVF TMATLRQLST MHPVHKILPN TLVIFVKVNF
YTCGLCGTIL PALSIGGGGH FKLGGKGLKA LTYRHLCILK DVADRGVGDL PSYYYRDDAC
SIWKTIHKFV DKILAIFYKS DEDVRGDAEL QAFVDDINHA LLSNPSNGFP TKFTCVSELS
EFLTMVVFLC SAQHSAVNYG QFDFYAWIPN APSAMRKPPP ATKGVVDMPF ILQTLPDVQV
SCVSMALTWV LSRSAAEKTL GTFQDEPFQN PDALKAMQEY QSDLEVITKS IVERNKTLPI
KYPYLKPDKV ANSITI
//
