ID   S4RNV9_PETMA            Unreviewed;       616 AA.
AC   S4RNV9;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0000259|SMART:SM01360};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000006895.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000006895.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; S4RNV9; -.
DR   STRING; 7757.ENSPMAP00000006895; -.
DR   Ensembl; ENSPMAT00000006925.1; ENSPMAP00000006895.1; ENSPMAG00000006257.1.
DR   GeneTree; ENSGT00940000155926; -.
DR   HOGENOM; CLU_423108_0_0_1; -.
DR   OMA; EINSHWI; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF179; LD23292P; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT   DOMAIN          195..286
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   616 AA;  67885 MW;  F72D762803D110AD CRC64;
     VSQQVVSMGQ VLEAGVARFP QFTLTPSSAW GPVVFIIVYY GTDDGYIVHE GVQLRVQDLE
     NKVEVKWSTT TAQPGTSVSL QVTASDPQSF IGVIALPKTL IILCNGNSSI MIRFTCCLSQ
     QNQYYDYNYY WWWTSNIFEA AGLSYVTNGN MDYWNEFCIT TYFLICTPFL DKPPINNGKS
     RKLENRLLND GLLDTWFWQN GVLGPDKTIT FTATAPEINS HWIAIAFSIS NTSGLSVDYT
     STPFEVTSPL QVTINVPSVT FLGEEFIVEA TVFNKQTQTA QVLAKLMENE NFTILFQSNG
     LSPNERSLNV SGQSSATAFF PVSLNVDGKV SFAVVVSYQN VDYTVVGYTL VKYPGFPQTY
     SESALLSLYE NKKFTRSFVF NFPPNIVQGS SSAVLYIYGD IIGPSLTGLD QLIQMPYGCG
     EQNMINFAPG IYIRIYLDVS RQTTPDIAAK SLNYMNSGYE RELMYRRSDG SFSAFGNSDQ
     QGSTWLTAFV LRTFLQARSY IPVDSNVIDT ARNFLLNSLA PSGQFTEHGY VIHRELQGGS
     ASHISLTAYT LLAFLEDSTA ENNNVNISSA IHFLEANVSG GGVAASLPLA LTAYALSLAN
     SSHAETALTL LNSRST
//