ID S4RPY7_PETMA Unreviewed; 1172 AA.
AC S4RPY7;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Regulator of G protein signaling 12 {ECO:0000313|Ensembl:ENSPMAP00000007273.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000007273.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000007273.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; S4RPY7; -.
DR STRING; 7757.ENSPMAP00000007273; -.
DR Ensembl; ENSPMAT00000007305.1; ENSPMAP00000007273.1; ENSPMAG00000006584.1.
DR GeneTree; ENSGT00940000159741; -.
DR HOGENOM; CLU_002190_0_0_1; -.
DR OMA; HKSEWSK; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd08706; RGS_R12-like; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR PANTHER; PTHR45945:SF3; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 21..98
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 697..814
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 916..986
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 988..1058
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 166..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1172 AA; 128226 MW; CF416FCE5A73028E CRC64;
SALGQARPVG LAGHRREDLH TVELARGPLG YGFTVVARAP CLVNCVLPGG PADVAGLRAG
DQIVAINDKD VSCASHHGVV ALIGQSLHTL KLVMAQNCNK PYVLLNNEAS PCKYRESFEL
DGVIKGAPIF HKMENNHSLM TDERLPPPHR AQSLVYPIVA VPHAGSGDGG RELPSRWEGT
DDPDDSLSGD VDLLTVKLIV CYLGSVELPS FDMDAEVEVL STIQSCLQRL RTKHRIHSLL
LMKILQDCIQ LYNEEHALIA TYSADKLAFS VVCPYDRNVV GIVTIAHVDD TAGEGGALRM
SCHVFFIDPT LSAHSCHVSV AQQFSFECTP DPDTNGCLEF GDSSQTLLQF VSVLYREMGE
VIEKIRAVAF ADVGHTELEA KRSVYSLNSD SGIGGFGMET GEITNFILLI RVCSTTTLHT
QGTVASDGGG PRACAVTGPG TAARGAADVE GPQPAETQTE QEQGAWNTRR RAGTGRAARG
AWVGRARAGP REGVMAAGCR FIHQESRSLL PHHACRIMEC DHNTDSKDPI LNSLTTWVNT
AAEPPPPPAL TGRYRQGLFP PRCPPPLSAL RRPGSRFPVP RAALRPCTSG VPCSLPLLCL
RLGRPTSLGV GHSPSRCRPR SRNVARSRTA RTPPYLPPRA QNARGPTVCR PELDRGELNS
SSSQQSVSSN ASLPSALSVR RQQQLSYEGR VASWALSFER LLHDPLGLRY FTEFLKKEFS
EENILFWLAC EQFKQTAYHD KHTLREKARE IFHAFLSRRA PNPVNIDSHG QLCERMLQDP
HAHMFLEQQQ QIFSLMKFDS YARFLKSALY QHCLLAEVGG HPLPSLASPA VSPPASQLTA
NQASAAIPDQ LSGVCTGLGT KYDIGFEQGN CEQARYNCHD RDGIIKPVEE LNSVLRTDSK
LIPILCLQMC MQQSRDGKCN VLPDGHSATL HVRPRLSIRE LLRPLCEQRG LPLAATDVFL
LGGEKPLVME QESSSLAMRE IRLEPRTLFR LDLVPINRSV GVKAKPTKAV TEVLKPIVTK
YGMKLEDLVA TMEGQSVPLD LGIAVSSLDG QRVVLDTRRQ LRTQQGGDTT ERGHTPPATA
HVLASSPVQV RSGNEKKSYA RHISTAKAIF GSGEKCDNSS KQTYISRKKK TGTKMDDVEE
LFEILVKAQS NRVNDQRGLL CKEDLILPDF LK
//
