ID   S4RSW2_PETMA            Unreviewed;       415 AA.
AC   S4RSW2;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) {ECO:0000313|Ensembl:ENSPMAP00000008302.1};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000008302.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000008302.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the ubiquitin conjugation factor E4 family.
CC       {ECO:0000256|ARBA:ARBA00007434}.
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DR   AlphaFoldDB; S4RSW2; -.
DR   STRING; 7757.ENSPMAP00000008302; -.
DR   Ensembl; ENSPMAT00000008340.1; ENSPMAP00000008302.1; ENSPMAG00000007524.1.
DR   GeneTree; ENSGT00390000009300; -.
DR   OMA; ESSEWSN; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR   CDD; cd16658; RING-Ubox_UBE4B; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR019474; Ub_conjug_fac_E4_core.
DR   InterPro; IPR045132; UBE4.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13931:SF2; UBIQUITIN CONJUGATION FACTOR E4 B; 1.
DR   PANTHER; PTHR13931; UBIQUITINATION FACTOR E4; 1.
DR   Pfam; PF04564; U-box; 1.
DR   Pfam; PF10408; Ufd2P_core; 1.
DR   SMART; SM00504; Ubox; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT   DOMAIN          318..391
FT                   /note="U-box"
FT                   /evidence="ECO:0000259|PROSITE:PS51698"
FT   REGION          150..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          387..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   415 AA;  48904 MW;  54F291B855D51578 CRC64;
     DLATFLLVFV CSHTYLRNPY LLAKLVEVLF VLNPSVQPRT TRFHEMLENH QLGTRHLAPS
     LMKFYTDVEQ TGASSEFYDK FTIRYHISAI FKSLWSNPAH QATFLEEFNS GSQFVRFINM
     LINDTTFLLD ESLDSLKRIH ELQEEMRNKE AWDRLSQEQQ QSRASQMSQD ERQCRSYLTL
     AMETLDMFHY LTKQVQKPFM RPELSDRLAA MLNFNLQQLC GPKCRDLKVE SPEKYGFEPR
     RLLDQLTDIY LHLDSPEFAH AIANDERSYR KELFEDAVGK MKKAGIKTTI AVERFRLLAE
     RVDEMVQHNV QADHDYSDAP EEFRDPLMDT LMRDPVRLPS GKVMDRSIII RHLLNAHTDP
     FNRQPLDETM LVPETELKER IQAWMREKHN KKAKNTQHDD EKEKTEITFH LKSDD
//