ID   S4RV35_PETMA            Unreviewed;      1095 AA.
AC   S4RV35;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Karyopherin (importin) beta 3 {ECO:0000313|Ensembl:ENSPMAP00000009075.1};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000009075.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000009075.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; S4RV35; -.
DR   STRING; 7757.ENSPMAP00000009075; -.
DR   Ensembl; ENSPMAT00000009114.1; ENSPMAP00000009075.1; ENSPMAG00000008184.1.
DR   GeneTree; ENSGT00940000155502; -.
DR   HOGENOM; CLU_003794_0_0_1; -.
DR   OMA; PKRFVQE; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040122; Importin_beta.
DR   InterPro; IPR041653; Importin_rep_4.
DR   InterPro; IPR040928; Importin_rep_5.
DR   InterPro; IPR041389; Importin_rep_6.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF5; IMPORTIN-5 ISOFORM X1; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF18808; Importin_rep_4; 1.
DR   Pfam; PF18816; Importin_rep_5; 1.
DR   Pfam; PF18829; Importin_rep_6; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ   SEQUENCE   1095 AA;  122187 MW;  A309301FF28A24B6 CRC64;
     LLAPSQASML FLGGFTNIPH AIGKRSTPEA YEAIPGPSKL SFLMSAVRNG SGAEETRQMA
     AVLARRLLSS SFEEVHPALP PELQLALRQQ LLLGAQDASL SPNLRAKISD IIAELARNLI
     DDDGNNQWPE VLKFLFDCVS SQNPLLREAA LHIFWNFPGI FGNQQQHYID VIKQMLVQCI
     QDQENPKVRI QAAKATASFV LSQEHLPVQK HFADLLPGIL QAVKDSLLLL DDDSVLKSLV
     DLADTCPKYL KGHLEDTLKL ALQICEDSNM GNMRRHLGLE VIVTLAEAAP AMLRKQKEII
     SLAVIRMLDL MVDLEDNELW STCDELEDED YDSNAVAGES ALDRLACGLG GKTVLPYVTP
     RIGSMLPSQD WKHRHAALMA LSAIGEGCHQ QMESMLPEIL NYVLPFLSDP HPRVRYASCN
     ALGQMATDFA PTFQKKFHDK VVSGLLMAIK DNDNPRVQAH AAAALINFTE DCPKTYLLPY
     LDSLLDHLEA ILNVKLQEMV MNGKKLVLEQ VVTAVASVAD TVEERFVLHY DRFMPKLKYI
     VERATEKEMR LLRGKTIECI SLIGLAVGQQ KFMADAAAVM QLLLNTQTES TQLEDDDPQI
     SYMISAWARM CKILGKDFQQ YLPVVMGPLL KTASMKPEVA LLDAQDMEEM EDDSWEFVSL
     GDQQSFGIKT AGLEEKATAC QMLVCYAREL KEGFAEYTEQ VVKLMVPLLK FYFHDGVRMA
     AAESLPLLLE CARIRGPEYL AEMWHFMCGD FIKAIGTEPD SDVISQIMES FARCVELMGE
     GCLDKEHFVE LGNILKAKLE EHFKNQELRQ EKRKDEDYDE QVEETLQDED NSDVYTLSKV
     SDILHAIFTC YKETVLPWFD LFLPLIVSLI DRNRPWADRQ WGFCVFDDLI ECCGPASLKY
     SEYFLRPMLE GVCESSAEVR QAAAYGVGVM AQHGGPGYAP ACTEALGLLM QVIQDSQSRV
     KENINATENC ISAVGKLLKF RPDCVNTQEF LPLWLSWLPV TEDKEEAVFC YNYLCDLIES
     NNPLVLGLNN ANLPSILAII AQGVANEATS EDAACTARLV SVVRQVQASG ELWAACLSQL
     DKEQQQFLDS LLSAA
//