ID S4RVV0_PETMA Unreviewed; 1039 AA.
AC S4RVV0;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Trio Rho guanine nucleotide exchange factor a {ECO:0000313|Ensembl:ENSPMAP00000009340.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000009340.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000009340.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; S4RVV0; -.
DR Ensembl; ENSPMAT00000009380.1; ENSPMAP00000009340.1; ENSPMAG00000008478.1.
DR GeneTree; ENSGT00940000154766; -.
DR HOGENOM; CLU_000373_3_0_1; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 2.
DR Gene3D; 1.20.58.60; -; 3.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF210; CRAL-TRIO DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00435; Spectrin; 3.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 4.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 3.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT DOMAIN 1015..1039
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
SQ SEQUENCE 1039 AA; 117560 MW; 75D05BE716E1DB11 CRC64;
GAVANDGPAM DSVLPLLKDK VAYLSGGRDR QGGPIIMFPA RGSLERARPD DLRELIAYLA
SVPSEEAGRR GFTAVVDMRG SKWEGVKLLL RTLQDALPGR VHAALIIKPD NFWQKQKTNF
GSSKFEFETA LVSVDGLARV VDLAQLTSEL DGSLDYRHEE WLEMRGAAER LAGRARHLLS
RLEELQEMLA RKDSPGELER ARQLASEHAR LKRTVLAAPV EALEQETRRL VARVRSGDAQ
AFPRCNPDLQ ALGPWLAGLT ERLHTTRQHL HQVWHVRKLK LDQCFQLRLF EQDADKMFDW
IEHNKELFLK SCTEMGSGHQ HASELHTQHS HFAMNSMNAY VNINRIVSVA GRLAEGGHYA
AQQLRQTAER LQREWKGFTA AIDERSLLLS MSVRFHLRGE QFQANVDGWC KACGEGALPS
DIHSLEAAIL RHQGLSDEIG QAYAEVSREG KSLLEKLQRP LSPGSAESLT ASANYSGAVQ
LILDCVPMED FFDERGVRLQ LLLRFRSFER EATEVMSSLS VWHEEIERRS TEFSTEDPTE
AERRLRFHSD KSLGLNNLAL DLLAQGQGLM QCMLEEQAAG LEVVCEGDVD MCVRVQELLQ
CVQERRLQLE GSADLHRQRL EQCLQLCQLQ DEVKQVLSWI RNGESMLNAS LLSACSLEEA
ESLQREHEHF QVAIESLFPD RSLQQTHQSA LRVQQRAAAL LGAGHYATDA VRSCAEMVAQ
HWQRLLLRVE DRLKLVTASV AFYKTSQQVC SVLDSLEQEY KREDDWCGGS DKLGPGAEND
HVEPIIHKHL EQKEAFLKAC TLARRNAEVF LKCIHRNSVT QPGFLSPARG PEQQVKVILG
ELLQRENRVL HHWTVRKRRL EQCQQYVLFE RSAKQVLSWI HDTGEFYLST HSCTGQTPDE
SRALLQEHDS FSSSAKRVCV RVKLLLGLAE SFLAKGHAHA VDFRQWVTAV DKRYRDFSCR
AHKHRAALEA ALGLPPQANQ SLRPESGPAC LTGPEVKLRD ASHELNEEKR KSARRKEFIM
AELLQTEKAY VRDLHQCIE
//
