ID S4RY98_PETMA Unreviewed; 418 AA.
AC S4RY98;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=SPARC related modular calcium binding 1 {ECO:0000313|Ensembl:ENSPMAP00000010189.1};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000010189.1, ECO:0000313|Proteomes:UP000245300};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000010189.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR AlphaFoldDB; S4RY98; -.
DR STRING; 7757.ENSPMAP00000010189; -.
DR Ensembl; ENSPMAT00000010234.1; ENSPMAP00000010189.1; ENSPMAG00000009265.1.
DR GeneTree; ENSGT00390000018436; -.
DR HOGENOM; CLU_023483_0_0_1; -.
DR OMA; SEWEICI; -.
DR Proteomes; UP000245300; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 2.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR12352; SECRETED MODULAR CALCIUM-BINDING PROTEIN; 1.
DR PANTHER; PTHR12352:SF30; THYROGLOBULIN TYPE1 REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR Pfam; PF00086; Thyroglobulin_1; 2.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 2.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000245300};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 26..78
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 79..142
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 206..274
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 113..120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 122..142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 244..251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 418 AA; 46992 MW; D7B4638F82E770E2 CRC64;
PLTPRHASPP PLCSPPPPTP SKFLIDDREN KCSAPCVGAL PKPLCASNGR TYESRCEFQR
AKCKEPQLEV TRRGRCPEMS SCQQDRARAQ ERQDKNSFIP ECKEDGTYAE VQCHSSTGYC
WCVTSEGRPI SGTSVRNTLP KCTGIERNRV IQRNGMGKAV SRSAHGSLQT RPAGQSETIS
GPTIWRNHLQ RGRENIYEKN SVSYKNPSCD QERQIATEEV RKNPREGIFV PECAAGGVYR
PVQCHQSTGY CWCVYVDTGR PIPGTSARYK LPECDGNARA RSKLEDPFRD RELEGCPGVK
KNEFVTSLLD ALTTDMVNAI NSKTAGSLRT HARRFSEPNP SHTLEERVVH WYFGTLDLDE
DERVDRRENK PLKRLAKRKG KPRRCSRKLV EHCDLNSDKV ISLAEMKGCL GVRRDEGE
//
