ID   S4S047_PETMA            Unreviewed;       819 AA.
AC   S4S047;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Ras protein specific guanine nucleotide releasing factor 1 {ECO:0000313|Ensembl:ENSPMAP00000010838.1};
OS   Petromyzon marinus (Sea lamprey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX   NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000010838.1, ECO:0000313|Proteomes:UP000245300};
RN   [1] {ECO:0000313|Ensembl:ENSPMAP00000010838.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; S4S047; -.
DR   STRING; 7757.ENSPMAP00000010838; -.
DR   Ensembl; ENSPMAT00000010884.1; ENSPMAP00000010838.1; ENSPMAG00000009861.1.
DR   GeneTree; ENSGT00940000157599; -.
DR   HOGENOM; CLU_003405_0_1_1; -.
DR   OMA; YHENDDP; -.
DR   Proteomes; UP000245300; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245300}.
FT   DOMAIN          64..251
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          281..411
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          458..574
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
SQ   SEQUENCE   819 AA;  90530 MW;  E48E8363AFBE986C CRC64;
     VVSLNRSKER LYAVGEDSDD EDEDPDIRKI KKVQSFLRGW LCRRKWKAIV QDYIRSPQAE
     SRRKRNQLVF SMLEAEGEYV AQLRVLVTGF LRPLRMAASS KRPPICHDDV SAVFLNSETI
     MFLHQIFHQG LKARIASWPT IVLADLFDML LPMLNIYQEF VRNHQFSLQV LANCKQNREF
     DKLLKQYESR AECEERTLET FLTFPMYQQI PRYIVTLHEL LAHTPQEHVE RRSLEFAKSK
     LEELSRIIHD EVSETENIRK NLAIERMIVE GCGILLDTSQ TFVRQGSLLQ VSTAEKGRMS
     RGRLGSLTSK KEGERQCFLF TKHLIICTRA SGGKLHLNKN GGVLPLLNCT LLEDLEPADD
     EAPTSSARSA VQDLEFRLAI EAGDTPPCIV LVAASRQQKA AWTSDISQCI DNLRCNGLMM
     NVFEDNSKIS VPQMVRSDRS LYCDGADIRF SRTLDSCKVP VIRAASVSRL LERLTDPRFL
     SIDFLNTFLY SYRVFTTATA LLARLAAGYR RPLSAVPVKD SLELFFSSSL PGRPHYGEPP
     KSPRACRKFS TPLSPTSPPG AVIAAIATSP PPGTSGGSAV IVGVSVSVSE APVASDTDAD
     ASPLAATPAA AGAAVSEPAS PLTSPTCLPA PGAIAGVPSP FRGRRKMSLN APLIHEPPVH
     AALPRGADDA AASSAGSPDG RGGSGTIFFF FLFSFPQKGV FELCPVAGRC ATIQEFPLFH
     VGSTAEVGGE TQEKIRRLSL AGTRGFSIAE HRMLDKEFII RRAVTNRVLN VLRHWVSKHS
     QDFESDSDLK SAVVRLLEEI SRDTELIGQE RKAAANILR
//